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Related Experiment Video

Updated: May 25, 2026

Pre-Conditioning the Airways of Mice with Bleomycin Increases the Efficiency of Orthotopic Lung Cancer Cell Engraftment

Pre-Conditioning the Airways of Mice with Bleomycin Increases the Efficiency of Orthotopic Lung Cancer Cell Engraftment

Published on: June 28, 2018

Cell-based therapies for lung disease.

Orquidea Garcia¹, Gianni Carraro, Sonia Navarro

¹Developmental Biology and Regenerative Medicine Program,The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA 90027, USA.

British Medical Bulletin

|January 27, 2012

Summary

This summary is machine-generated.

Lung regenerative medicine explores stimulating endogenous stem cells or using exogenous cells for repair. Tissue engineering with scaffolds offers an alternative for lung replacement when repair is not possible.

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Generation of Human 3D Lung Tissue Cultures (3D-LTCs) for Disease Modeling

Generation of Human 3D Lung Tissue Cultures (3D-LTCs) for Disease Modeling

Published on: February 12, 2019

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Last Updated: May 25, 2026

Pre-Conditioning the Airways of Mice with Bleomycin Increases the Efficiency of Orthotopic Lung Cancer Cell Engraftment

Pre-Conditioning the Airways of Mice with Bleomycin Increases the Efficiency of Orthotopic Lung Cancer Cell Engraftment

Published on: June 28, 2018

Generation of Human 3D Lung Tissue Cultures (3D-LTCs) for Disease Modeling

Generation of Human 3D Lung Tissue Cultures (3D-LTCs) for Disease Modeling

Published on: February 12, 2019

Area of Science:

Regenerative Medicine
Stem Cell Biology
Tissue Engineering

Background:

The adult lung has slow epithelial cell turnover despite high environmental exposure.
Age-related lung function decline presents a significant healthcare challenge.
Cell-based therapies and tissue-engineered lungs are key goals for lung repair and replacement.

Purpose of the Study:

To characterize endogenous and exogenous stem cells for lung therapy.
To explore seeding decellularized lung tissue or bioengineered matrices with stem cells.
To advance cell-based approaches for treating respiratory diseases.

Main Methods:

Defining developmental lineages, surface markers, and functions of lung stem/progenitor cells.
Investigating cellular responses to lung injury and disease.
Utilizing decellularized lung tissue and bioengineered scaffolds for cell seeding.

Main Results:

Cellular therapies show promise for respiratory diseases.
Lung regenerative medicine focuses on stimulating resident cells, transplanting exogenous cells, and repopulating engineered matrices.
Challenges include defining specific stem cell markers and proving therapeutic effectiveness.

Conclusions:

Further research is needed in lineage tracing, directed differentiation, and functional assays for lung stem cells.
Standardizing assays and understanding cell-matrix interactions are crucial for lung engineering.
Realistic communication of cell-based therapy potential is essential for patients with end-stage lung disease.