Peripheral T-cell lymphomas: a clinicopathologic study of 75 cases

Area of Science:

• Hematology
• Oncology
• Pathology

Background:

• Peripheral T-cell lymphomas (PTLs) are a heterogeneous group of non-Hodgkin's lymphomas.
• Accurate classification is crucial for understanding prognosis and guiding treatment.
• The Updated Kiel Classification provides a framework for PTL subtyping.

Purpose of the Study:

• To classify 75 peripheral T-cell lymphomas (PTLs) according to the Updated Kiel Classification.
• To analyze the clinical presentation, immunophenotype, and prognostic factors in PTL.
• To evaluate treatment outcomes and survival rates based on PTL subtypes and characteristics.

Main Methods:

• Seventy-five PTL cases were classified using the Updated Kiel Classification (excluding mycosis fungoides and Sezary's syndrome).
• Immunophenotyping was performed using pan-T cell markers (UCHL 1, MT 1).
• Clinical data, including presentation, staging, bone marrow involvement, and treatment response, were analyzed. Ki-67 positivity was assessed as a prognostic marker.

Main Results:

• Thirty-seven PTLs were low-grade and 38 were high-grade.
• Loss of pan-T antigens was observed exclusively in high-grade PTLs.
• Pleomorphic medium and large cell PTL showed the poorest median survival (8 months). B-cell lymphoma symptoms, bone marrow involvement, and high Ki-67 (≥60%) significantly shortened survival.

Conclusions:

• The Updated Kiel Classification effectively categorizes PTLs.
• High-grade PTLs exhibit distinct immunophenotypic features and aggressive behavior.
• Ki-67 reactivity is a significant prognostic indicator for PTL, predicting poor outcomes, particularly in early-stage disease.