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Interaction between gentamicin and mycophenolate mofetil in experimentally induced pyelonephritis

H Malekinejad1, A Nikibakhsh, S Gholizadeh-Soltani

  • 1Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.

Indian Journal of Nephrology
|January 27, 2012
PubMed

Insights

Gentamicin and ceftriaxone effectively treat acute pyelonephritis (APN) in rats. However, combining gentamicin with mycophenolate mofetil worsened kidney function, suggesting potential compound incompatibility in APN treatment.

Area of Science:

  • Nephrology
  • Pharmacology
  • Infectious Diseases

Background:

  • Acute pyelonephritis (APN) is a serious kidney infection causing inflammation and potential malfunction.
  • Effective antibiotic treatment is crucial for managing APN and preventing kidney damage.

Purpose of the Study:

  • To assess the therapeutic effects of gentamicin (GEN) and ceftriaxone (CEF) alone and combined with mycophenolate mofetil (MMF) in an experimental APN model.
  • To investigate potential adverse interactions between antibiotics and immunosuppressants in APN.

Main Methods:

  • Acute pyelonephritis was induced in Wistar rats using E. coli injection.
  • Rats were treated for two weeks with saline, GEN, CEF, MMF, or combinations (GEN+MMF, CEF+MMF).
  • Kidney function was evaluated via blood counts, creatinine, BUN levels, and histopathology.

Main Results:

  • GEN and CEF treatment normalized elevated white blood cells, creatinine, and BUN levels in APN rats.
  • Co-administration of GEN with MMF significantly increased creatinine and BUN, indicating worsened kidney damage.
  • Histopathology confirmed that GEN and CEF alone partially restored kidney tissue, while GEN+MMF combination therapy failed to reduce APN-induced damage.

Conclusions:

  • Gentamicin and ceftriaxone are effective in treating experimental acute pyelonephritis.
  • Combining gentamicin with mycophenolate mofetil may exacerbate kidney damage in APN, possibly due to compound incompatibility.
  • Further research is needed to understand the adverse effects of combined therapeutic regimens in APN.
Keywords:
Acute pyelonephritisE. coliceftriaxonecombination therapygentamicinmycophenolate mofetil

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