[Use of regulators of the nitric oxide synthesis in experimental hemorrhagic shock and its infusion therapy]

In a model of volume-controlled hemorrhagic shock in rats bolus injection prior to hemorrhagic of non-selective inhibitor of the nitric oxide synthases--N-Nitro-L-Arginine at the dose 250 mg/kg promotes considerable blood flow redistribution and rapid death of animals. However the donor of nitric oxide--L-Arginine (300 mg/kg) enchances stability of animals in hemorrhagic shock. Infusion of L-Arginine (300 mg/kg) with physiological salt solution after bleeding restored cardiac function and microcirculation in the serous membrane of the small intestine of rats. These data suggest that generation of nitric oxide in early stage of hemorrhagic shock may be protective reaction for supporting of normal perfusion of tissues.