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Related Concept Videos

Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Bone Cells and Tissue01:30

Bone Cells and Tissue

Bones contain a relatively small number of cells entrenched in a matrix of organic and inorganic components. Although bone cells compose only a small amount of the bone volume, they are crucial to its function. Four types of cells are found within the bone tissue— osteoblasts, osteocytes, osteogenic cells, and osteoclasts.
Osteoblasts and Osteocytes
The osteoblast is the bone cell responsible for forming new bone tissue. It is found in the growing portions of bone, including the periosteum and...
Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview

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Related Experiment Video

Updated: May 25, 2026

Osteoclast Derivation from Mouse Bone Marrow
06:17

Osteoclast Derivation from Mouse Bone Marrow

Published on: November 6, 2014

The tight relationship between osteoclasts and the immune system.

Andrea Del Fattore1, Anna Teti

  • 1Regenerative Medicine Unit, Ospedale Pediatrico Bambino Gesù, Rome, Italy.

Inflammation & Allergy Drug Targets
|January 28, 2012
PubMed
Summary

Osteoimmunology reveals intricate links between bone and immune systems. Osteoclasts, bone-resorbing cells, share immune cell traits, suggesting a role in innate immunity and bone remodeling.

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Differentiation of Functional Osteoclasts from Human Peripheral Blood CD14+ Monocytes
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Differentiation of Functional Osteoclasts from Human Peripheral Blood CD14+ Monocytes

Published on: January 27, 2023

Related Experiment Videos

Last Updated: May 25, 2026

Osteoclast Derivation from Mouse Bone Marrow
06:17

Osteoclast Derivation from Mouse Bone Marrow

Published on: November 6, 2014

Differentiation of Functional Osteoclasts from Human Peripheral Blood CD14+ Monocytes
11:52

Differentiation of Functional Osteoclasts from Human Peripheral Blood CD14+ Monocytes

Published on: January 27, 2023

Area of Science:

  • Osteoimmunology
  • Skeletal biology
  • Immunology

Background:

  • The skeletal and immune systems exhibit complex bidirectional regulatory mechanisms.
  • Inflammatory diseases significantly impact bone metabolism, with cytokines mediating communication.
  • Osteoclasts, derived from monocytes/macrophages, show immune cell characteristics and relationships.

Purpose of the Study:

  • To explore the close association between the skeletal and immune systems.
  • To investigate the immune cell-like properties of osteoclasts.
  • To understand the role of osteoclasts in bone resorption and immunity.

Main Methods:

  • Review of existing literature on osteoimmunology.
  • Analysis of the relationship between osteoclasts and immune cells.
  • Examination of cytokine and cellular signaling in bone remodeling.

Main Results:

  • Osteoclasts share lineage and differentiation pathways with immune cells (e.g., RANKL).
  • Osteoclasts express immune co-receptors, supporting their immune cell-like nature.
  • Bone matrix may trigger innate immune responses via osteoclast-like cells.

Conclusions:

  • Osteoclasts possess significant immune cell characteristics, suggesting a dual role.
  • The precise function of osteoclasts in bone resorption remains an area of investigation.
  • Osteoclast activity is tightly regulated by immune and skeletal factors.