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Pathophysiologic therapeutic targets in hypertension: a cardiological point of view

Gabriele Fragasso1, Francesco Maranta, Claudia Montanaro

  • 1Heart Failure Clinic, Istituto Scientifico San Raffaele, via Olgettina 60, 20132 Milano, Italy. gabriele.fragasso@hsr.it

Expert Opinion on Therapeutic Targets
|January 28, 2012
PubMed

Insights

Treating arterial hypertension requires considering individual pathophysiological mechanisms. Inhibitors of the renin-angiotensin-aldosterone system are recommended for complex hypertensive patients, especially those at high risk.

Area of Science:

  • Cardiology
  • Pharmacology
  • Hypertension Management

Background:

  • Arterial hypertension treatment is complex, requiring tailored approaches based on patient-specific pathophysiology.
  • Understanding pathophysiological mechanisms is crucial for effective anti-hypertensive therapy.

Purpose of the Study:

  • To review the relationship between hypertension pathophysiology, medical treatment, and drug side effects.
  • To identify optimal pharmacological strategies for managing arterial hypertension.

Main Methods:

  • Literature search of Medline and Cochrane library (1986-2011).
  • Focused on papers detailing hypertension pathophysiology, treatment, and adverse effects of anti-hypertensive drugs.

Main Results:

  • Hypertension often coexists with complex health issues like diabetes and dyslipidemia.
  • Changes in pathophysiological markers can predict patient clinical outcomes.

Conclusions:

  • Hypertensive patients, particularly those with complex conditions, require holistic pharmacological treatment.
  • Renin-angiotensin-aldosterone system inhibitors are suggested as a primary treatment for high-risk hypertensive patients.
Abstract

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