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Updated: May 25, 2026
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Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
Published on: February 13, 2021
Diastolic heart failure and LV dyssynchrony.
Mario Kasner1, Dirk Westermann, Heinz-Peter Schultheiss
1Department of Cardiology and Pneumology, Benjamin Franklin Campus, Charité University Hospital, Berlin, Germany.
Current Pharmaceutical Biotechnology
|January 28, 2012
Summary
Diastolic heart failure (DHF) understanding is limited. Left ventricular (LV) dyssynchrony, both systolic and diastolic, may impair cardiac function in DHF patients, but its exact role needs further research.
Area of Science:
- Cardiology
- Heart Failure Research
Background:
- Knowledge regarding the pathophysiology, diagnosis, and treatment of diastolic heart failure (DHF) remains limited.
- Left ventricular (LV) dyssynchrony has been proposed as a contributing factor in the pathogenesis of DHF.
Purpose of the Study:
- To explore the role of LV dyssynchrony in diastolic heart failure.
- To investigate the prevalence and impact of systolic and diastolic dyssynchrony in DHF.
Main Methods:
- The study likely involved analyzing patient data to detect and quantify LV dyssynchrony in DHF.
- Assessment of systolic and diastolic dyssynchrony using relevant diagnostic tools.
Main Results:
- Systolic LV dyssynchrony is detected in 20-30% of DHF patients, while diastolic dyssynchrony is present in about 20%.
- Dyssynchrony, both systolic and diastolic, can impair cardiac function and influence clinical presentation in DHF.
- Unlike systolic heart failure, wide QRS complexes are uncommon in DHF, suggesting dyssynchrony relates to regional contractility variations.
Conclusions:
- LV dyssynchrony, particularly mechanical dyssynchrony in patients with preserved LV contractility, contributes to energy wastage and reduced cardiac reserves.
- The precise extent to which LV dyssynchrony participates in the pathomechanisms of DHF requires further investigation.
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