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Updated: May 25, 2026
10:39
3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
Headache and adverse pregnancy outcomes: a prospective study
Luca Marozio1, Fabio Facchinetti, Gianni Allais
1Department of Obstetrics and Gynecology, University of Turin, Via Ventimiglia 3, Turin, Italy. luca.marozio@unito.it
European Journal of Obstetrics, Gynecology, and Reproductive Biology
|January 28, 2012
Summary
Pregnant women experiencing headache, including migraine and tension-type headache, face a higher risk of preterm delivery. These findings suggest enhanced monitoring for high-risk pregnancies.
Area of Science:
- Obstetrics and Gynecology
- Neurology
- Perinatal Medicine
Background:
- Headache disorders, including migraine and tension-type headache, are common in pregnancy.
- The impact of these headaches on adverse pregnancy outcomes requires further investigation.
Purpose of the Study:
- To examine the association between headache (migraine and tension-type) and adverse pregnancy outcomes.
- To determine if headache in pregnancy necessitates a high-risk pregnancy protocol.
Main Methods:
- A prospective cohort study involving 376 pregnant women with headache and 326 controls.
- Headache diagnosis followed International Classification of Headache Disorders (ICHD-II) criteria.
- Outcomes included preterm delivery, small for gestational age newborns, and fetal loss.
Main Results:
- Headache was significantly associated with a higher incidence of preterm delivery (Adj OR, 95% CI 2.74, 1.27-5.91).
- No significant difference was observed in newborns small for gestational age between groups.
- The association between headache and adverse perinatal outcomes remained significant, irrespective of pre-eclampsia.
Conclusions:
- Women with headache during pregnancy are at increased risk for adverse perinatal outcomes.
- Inclusion in high-risk pregnancy protocols is recommended for pregnant women with headache.
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