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Chondroitin sulfate synthase 1 (Chsy1) is required for bone development and digit patterning

Deanna G Wilson1, Khanhky Phamluong, Wei Yu Lin

  • 1Genentech, South San Francisco, CA 94080, USA.

Developmental Biology
|January 28, 2012
PubMed
Summary

Chondroitin sulfate synthase 1 (Chsy1) is crucial for skeletal development and joint formation. Loss of Chsy1 in mice leads to limb patterning defects and ectopic joints, modeling human brachydactylies.

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