Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Gastrointestinal Motility Disorders01:20

Gastrointestinal Motility Disorders

Gastrointestinal or GI motility disorders are characterized by irregular gastrointestinal tract movements, disrupting food transit from the mouth to the anus. They are caused by damage or dysfunction in gut muscles or nerves. These disorders can cause symptoms such as severe constipation, diarrhea, abdominal pain, and swallowing difficulties. Disorders can affect any segment of the GI tract and range widely in severity, from common conditions like GERD to life-threatening conditions like...
Histology of the Gastrointestinal (GI) Tract01:20

Histology of the Gastrointestinal (GI) Tract

The GI tract, from beginning to end, is made up of four continuous tissue layers that adjust their structure according to their specific roles. These layers, from innermost to outermost, are known as the mucosa, submucosa, muscularis, and serosa, which are continuous with the mesentery.
The mucosa is sometimes called a mucous membrane due to its mucus-secreting features. This membrane is composed of epithelium, which directly interacts with ingested substances, and the lamina propria, a layer...
Stomach Histology01:26

Stomach Histology

The stomach comprises several layers that work together to facilitate digestion and protect the organ. The outermost layer is called the serosa, which provides support and protection to the stomach. The muscularis externa layer is responsible for the mechanical breakdown of food by contracting and moving the stomach. The submucosa layer, located beneath the muscularis externa, contains connective tissue, blood vessels, nerves, and glands that secrete mucus and other substances essential for...
Gastritis-II: Pathophysiology01:17

Gastritis-II: Pathophysiology

Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of smoking cessation on survival and treatment tolerability in advanced non-small cell lung cancer: a single-center experience from Morocco.

Ecancermedicalscience·2026
Same author

PARP Inhibitors in Metastatic Prostate Cancer: Bridging Biomarker Complexity and Clinical Decision-Making Through a Pragmatic Treatment Framework.

Cancers·2026
Same author

Epidemiological characteristics, prognostic factors, and survival of resectable colorectal cancer in a Moroccan population.

The Gulf journal of oncology·2026
Same author

Metastatic Mixed Germ Cell Tumour in a Patient with Cryptorchidism and Persistent Müllerian Duct Syndrome.

European journal of case reports in internal medicine·2026
Same author

Adenoid cystic carcinoma of the breast: a case report and literature review.

Oxford medical case reports·2026
Same author

The oncogeriatric transition in Morocco: health-system challenges and strategic priorities in an aging society.

Frontiers in public health·2026

Related Experiment Video

Updated: May 25, 2026

Molecular and Immunologic Techniques in a Genetically Engineered Mouse Model of Gastrointestinal Stromal Tumor
07:21

Molecular and Immunologic Techniques in a Genetically Engineered Mouse Model of Gastrointestinal Stromal Tumor

Published on: May 2, 2022

[Gastrointestinal stromal tumors].

Sakina Sekkate1, Mouna Kairouani, Halima Abahssain

  • 1Institut national d'oncologie, service d'oncologie médicale, 10100 Rabat, Maroc. sakina.sekkate@yahoo.fr

Presse Medicale (Paris, France : 1983)
|January 28, 2012
PubMed
Summary

Gastrointestinal stromal tumors (GIST) are common GI sarcomas originating from interstitial cells of Cajal. Treatment includes surgery for localized GIST, with imatinib and sunitinib as key therapies for metastatic and adjuvant settings.

More Related Videos

Robotic Duodenal Sleeve Resection for Gastrointestinal Stromal Tumor with Rare Exon 8 KIT Mutation Following Neoadjuvant Imatinib
06:43

Robotic Duodenal Sleeve Resection for Gastrointestinal Stromal Tumor with Rare Exon 8 KIT Mutation Following Neoadjuvant Imatinib

Published on: April 3, 2026

Related Experiment Videos

Last Updated: May 25, 2026

Molecular and Immunologic Techniques in a Genetically Engineered Mouse Model of Gastrointestinal Stromal Tumor
07:21

Molecular and Immunologic Techniques in a Genetically Engineered Mouse Model of Gastrointestinal Stromal Tumor

Published on: May 2, 2022

Robotic Duodenal Sleeve Resection for Gastrointestinal Stromal Tumor with Rare Exon 8 KIT Mutation Following Neoadjuvant Imatinib
06:43

Robotic Duodenal Sleeve Resection for Gastrointestinal Stromal Tumor with Rare Exon 8 KIT Mutation Following Neoadjuvant Imatinib

Published on: April 3, 2026

Area of Science:

  • Gastrointestinal Oncology
  • Molecular Pathology
  • Surgical Oncology

Context:

  • Gastrointestinal stromal tumors (GIST) represent the most frequent sarcomas within the digestive tract, impacting all its segments.
  • These tumors arise from the interstitial cells of Cajal, a specific cell type within the GI tract.
  • Genetic mutations, particularly in the Kit gene (86%) and PDGFR gene (15%), are frequently observed in GIST cases.

Purpose:

  • To outline the epidemiology, cellular origin, and genetic landscape of Gastrointestinal Stromal Tumors (GIST).
  • To detail the current standard treatment modalities for localized and metastatic GIST.
  • To highlight the role of targeted therapies in GIST management.

Summary:

  • GISTs are the most common gastrointestinal sarcomas, originating from interstitial cells of Cajal and often associated with Kit or PDGFR gene mutations.
  • The CD 117 marker is present in 95% of GIST cases, aiding in diagnosis.
  • Surgical resection is the primary treatment for localized GIST. For metastatic or adjuvant settings, imatinib is the first-line standard, with sunitinib used as second-line therapy.

Impact:

  • Provides a concise overview of GIST, crucial for clinicians and researchers in gastroenterology and oncology.
  • Emphasizes the importance of molecular markers (CD 117, Kit, PDGFR) in GIST diagnosis and treatment selection.
  • Clarifies the established treatment algorithm for GIST, including surgical and pharmacological interventions.