Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Cancer Therapies

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...

Infertility in Females

Infertility in Females

Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of endometrial...

Infertility in Males

Infertility in Males

Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...

Combination Therapies and Personalized Medicine

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...

Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists

Chemotherapy-Induced Nausea and Vomiting: 5-HT₃ Receptor Antagonists

5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

What may be the best menopausal hormone treatment?

Archives of gynecology and obstetrics·2022

Same author

Bi-allelic variants in the mitochondrial RNase P subunit PRORP cause mitochondrial tRNA processing defects and pleiotropic multisystem presentations.

American journal of human genetics·2021

Same author

Successful Delivery in 17,20-Lyase Deficiency.

The Journal of clinical endocrinology and metabolism·2021

Same author

Utility of gonadotropin-releasing hormone agonists for fertility preservation in women receiving chemotherapy: pros and cons.

Fertility and sterility·2020

Same author

Which medication and when should it be administered for reducing pain in intrauterine device insertion?

Fertility and sterility·2020

Same author

Possible impact of COVID-19 on fertility and assisted reproductive technologies.

Fertility and sterility·2020

Search research articles

Related Experiment Video

Updated: May 25, 2026

Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives

Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives

Published on: September 16, 2021

Chemotherapy and fertility.

Zeev Blumenfeld¹

¹Department of Obstetrics and Gynaecology, RAMBAM Health Care Campus, The Rappaport Institute, Technion - Israel Institute of Technology, Haifa Israel. bzeev@techunix.technion.ac.il

Best Practice & Research. Clinical Obstetrics & Gynaecology

|January 28, 2012

Summary

Fertility preservation is crucial for young women undergoing gonadotoxic chemotherapy. Combining methods like ovarian transposition and cryopreservation offers the best chance for future fertility in cancer survivors.

Area of Science:

Reproductive Endocrinology
Oncology
Cell Biology

Background:

Cancer treatments like chemotherapy and radiotherapy can cause infertility in young women.
This infertility is a significant long-term consequence of treating various malignancies.
Understanding the mechanisms of chemotherapy's damage to ovarian function is essential.

Purpose of the Study:

To review the impact of gonadotoxic chemotherapy on female fertility.
To explore current fertility preservation strategies for cancer patients.
To emphasize the need for combined approaches to maximize fertility outcomes.

Main Methods:

Literature review on gonadotoxic effects of chemotherapy agents.
Analysis of pathophysiologic mechanisms of ovarian damage.

More Related Videos

Collection of Human Follicular Fluid, Follicle Somatic Cells, and Immature Oocytes from Individuals Undergoing In Vitro Fertilization

Collection of Human Follicular Fluid, Follicle Somatic Cells, and Immature Oocytes from Individuals Undergoing In Vitro Fertilization

Published on: October 24, 2025

Related Experiment Videos

Last Updated: May 25, 2026

Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives

Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives

Published on: September 16, 2021

Collection of Human Follicular Fluid, Follicle Somatic Cells, and Immature Oocytes from Individuals Undergoing In Vitro Fertilization

Collection of Human Follicular Fluid, Follicle Somatic Cells, and Immature Oocytes from Individuals Undergoing In Vitro Fertilization

Published on: October 24, 2025

Evaluation of existing fertility preservation techniques.

Main Results:

Alkylating agents are particularly gonadotoxic, causing oocyte destruction and ovarian damage.
The risk of premature ovarian failure varies based on chemotherapy protocol and patient age.
Current fertility preservation methods include ovarian transposition, embryo/oocyte/tissue cryopreservation, and GnRH agonist administration.

Conclusions:

No single fertility preservation method guarantees success.
A combination of strategies is recommended to improve fertility chances for survivors.
Further research is needed to optimize fertility preservation in young women undergoing cancer treatment.