Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Target Cell Response to Hormones01:22

Target Cell Response to Hormones

Hormones intricately bind to receptors on the surface or within target cells, initiating a cascade of cellular responses.
Notably, the cellular response can be regulated by altering the number of receptors expressed in the cell. For example, prolonged exposure to elevated hormone levels results in a gradual decline or down-regulation in the number of receptors for that specific hormone on the cell surface. Conversely, in response to low hormone levels, cells may use up-regulation, producing an...
Major Hormones and Their Functions01:27

Major Hormones and Their Functions

Hormones, the biochemical messengers produced by endocrine glands, are pivotal in regulating bodily functions and maintaining homeostasis. Each hormone's balance is crucial; imbalances can lead to significant physiological disruptions. Major hormones include oxytocin, cortisol, epinephrine, estrogen, testosterone, thyroxine, growth hormone, insulin, and glucagon.
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and lactation.
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Regulation of Hormone Secretion01:19

Regulation of Hormone Secretion

Regulation of hormone secretion is a finely tuned orchestration driven by various types of stimuli, encompassing neural, humoral, and hormonal signals. Environmental cues instigate neural stimuli, where action potentials traverse nerve fibers to reach their designated targets. An illustrative scenario is the body's response to stress, wherein the sympathetic nervous system releases epinephrine from the adrenal glands, inducing the well-known 'fight or flight' reaction.
Humoral stimuli,...
Role of Skin in Vitamin D Synthesis01:23

Role of Skin in Vitamin D Synthesis

The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin D3(cholecalciferol).
Hormones Regulating Blood Glucose01:16

Hormones Regulating Blood Glucose

Insulin is released by beta cells of the pancreas when blood glucose levels are high. It facilitates glucose absorption and utilization in insulin-dependent cells with insulin receptors on their plasma membranes. Insulin promotes glucose uptake by increasing the number of glucose transport proteins in the cell membrane, allowing glucose to enter the cell. As a result, glucose utilization and ATP production are enhanced.
In addition to accelerating glucose uptake and utilization, insulin has...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Paracoccidioidomycosis manifested by sarcoid-like cutaneous lesions with severe systemic disease: a rare and challenging diagnosis.

Revista da Sociedade Brasileira de Medicina Tropical·2024
Same author

Prevalence of the association of vulvar lichen sclerosis with Hashimoto's thyroiditis.

Anais brasileiros de dermatologia·2024
Same author

Pigmented squamous cell carcinoma in a non-photo-exposed area of an indigenous woman.

Anais brasileiros de dermatologia·2023
Same author

Invasive clear-cell variant of squamous cell carcinoma mimicking sebaceous carcinoma.

Anais brasileiros de dermatologia·2023
Same author

Amelanotic nodular melanoma in Marjolin ulcer on the plantar region.

Anais brasileiros de dermatologia·2023
Same author

Cervical sporotrichosis simulating squamous cell carcinoma in a patient with photodamage.

Anais brasileiros de dermatologia·2022

Related Experiment Video

Updated: May 25, 2026

Comparative Analysis of Human Growth Hormone in Serum Using SPRi, Nano-SPRi and ELISA Assays
11:17

Comparative Analysis of Human Growth Hormone in Serum Using SPRi, Nano-SPRi and ELISA Assays

Published on: January 7, 2016

Growth hormone system: skin interactions.

Guilherme Póvoa1, Lucia Martins Diniz

  • 1Department of Internal Medicine, Health Sciences Center, Federal University of Espírito Santo, Vitória, ES, Brazil. gbpovoa@bol.com.br

Anais Brasileiros De Dermatologia
|January 28, 2012
PubMed
Summary

This article reviews the role of the growth hormone system in skin biology. The authors examine how growth hormone interacts with skin cells and structures, focusing on its receptor and carrier proteins. They suggest that growth hormone may influence wound healing by promoting cell proliferation and tissue repair. The review highlights the presence of other proteins that modulate the hormone's activity in skin tissues. The findings indicate that growth hormone's effects on skin may depend on local concentrations and receptor availability. The authors propose that future research should explore these mechanisms in more detail. This work provides a foundation for understanding the hormone's potential dermatological applications.

Keywords:
Growth hormone signalingSkin wound healingDermal tissue interactionsHormone receptor function

Frequently Asked Questions

More Related Videos

Generation of Human Induced Pluripotent Stem Cell-derived Planar Hair-bearing Skin Organoids Using an Air-Liquid Interface Culture System
04:37

Generation of Human Induced Pluripotent Stem Cell-derived Planar Hair-bearing Skin Organoids Using an Air-Liquid Interface Culture System

Published on: October 17, 2025

Related Experiment Videos

Last Updated: May 25, 2026

Comparative Analysis of Human Growth Hormone in Serum Using SPRi, Nano-SPRi and ELISA Assays
11:17

Comparative Analysis of Human Growth Hormone in Serum Using SPRi, Nano-SPRi and ELISA Assays

Published on: January 7, 2016

Generation of Human Induced Pluripotent Stem Cell-derived Planar Hair-bearing Skin Organoids Using an Air-Liquid Interface Culture System
04:37

Generation of Human Induced Pluripotent Stem Cell-derived Planar Hair-bearing Skin Organoids Using an Air-Liquid Interface Culture System

Published on: October 17, 2025

Area of Science:

  • Endocrinology and hormone signaling
  • Dermatology and skin biology
  • Molecular and cellular interactions

Background:

The role of the growth hormone system in skin physiology remains partially understood. While growth hormone's systemic effects are well-documented, its localized impact on skin tissues has not been fully explored. Prior research has shown that growth hormone influences cellular proliferation and tissue repair in various organs. However, the specific mechanisms by which it affects the epidermis and dermis are not yet clear. This uncertainty has driven researchers to investigate how growth hormone interacts with skin cells and structures. No prior work has resolved the extent of growth hormone's involvement in wound healing processes. Understanding these interactions could help clarify the hormone's therapeutic potential in dermatological contexts. This gap motivated a comprehensive review of relevant studies on growth hormone signaling in skin tissues.

Purpose Of The Study:

The aim of this study was to examine the role of the growth hormone system in skin biology. Specifically, the researchers sought to identify how growth hormone interacts with epidermal and dermal tissues. They focused on the hormone's receptor and carrier proteins, as well as other proteins involved in its signaling pathways. This work aimed to clarify the potential effects of growth hormone on wound healing processes. The study also aimed to synthesize findings from existing literature on this topic. By reviewing available data, the authors hoped to highlight the mechanisms through which growth hormone might influence skin function. This approach allowed them to assess the current state of knowledge in this area. The ultimate goal was to provide a foundation for future investigations into growth hormone's dermatological applications.

Main Methods:

The researchers conducted a literature review to analyze the growth hormone system's interactions with skin tissues. They focused on studies examining the hormone's receptor and carrier proteins in dermal contexts. The review included investigations into the signaling pathways involved in growth hormone's effects. The authors synthesized findings from multiple studies on epidermal and dermal cell responses. They examined how growth hormone might influence wound healing processes. The review also considered the role of other proteins that modulate the hormone's activity. The researchers categorized the evidence based on the biological mechanisms described. This approach allowed them to identify patterns in how growth hormone affects skin structures.

Main Results:

The review suggests that growth hormone may influence epidermal cell function through receptor-mediated signaling. Evidence indicates that the hormone's receptor is present in dermal tissues, suggesting a direct role in skin physiology. The study highlights the involvement of carrier proteins in transporting growth hormone to target cells. Some findings propose that growth hormone may enhance wound healing by promoting cell proliferation. The review also notes the presence of other proteins that modulate the hormone's activity in skin tissues. These proteins appear to regulate the hormone's availability and signaling efficiency. The data suggest that growth hormone's effects on skin may depend on local concentrations and receptor availability. This synthesis provides a framework for understanding the hormone's potential dermatological roles.

Conclusions:

The authors propose that the growth hormone system may play a role in skin physiology and wound healing. They suggest that the hormone's receptor and carrier proteins are key components in its localized effects. The review indicates that growth hormone may influence epidermal and dermal structures through signaling pathways. The findings suggest that the hormone's activity in skin tissues is modulated by other proteins. The authors highlight the need for further research to clarify the exact mechanisms involved. They propose that future studies should investigate how growth hormone affects skin cell proliferation and repair. The synthesis of existing evidence supports the idea that the hormone's effects on skin are context-dependent. These conclusions provide a foundation for future investigations into growth hormone's dermatological applications.

The authors propose that growth hormone may influence skin through receptor-mediated signaling, potentially affecting cell proliferation and tissue repair.

The review suggests that carrier proteins transport growth hormone to target cells in the skin, modulating its availability and signaling efficiency.

The authors suggest that understanding growth hormone's role in wound healing could help develop new therapeutic approaches for skin repair.

The review indicates that other proteins modulate growth hormone activity, influencing its availability and signaling in dermal and epidermal tissues.

The authors suggest that growth hormone may influence epidermal cells through receptor-mediated signaling, possibly affecting proliferation and tissue repair.

The authors propose that future studies should investigate how growth hormone affects skin cell proliferation and repair mechanisms in more detail.