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Updated: May 25, 2026

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
Published on: January 22, 2018
HER-2/neu and TOPIIa expression in gastric cancer reflect disease severity
Hong-Qi Liu1, Shao-Lan Zhang, Shu Song
1Department of Oncology, the First People's Hospital, Yancheng, China. hongqiliu@126.com
Background/Aims:
Gastric cancer is associated with high morbidity and mortality, but reliable diagnostic and prognostic markers have not been established. Here we explored the clinical significance of two proteins, HER-2/neu and TOPIIa-associated with development and progression of various tumor types-in gastric cancer. We also analyzed the correlation between expression of these proteins and clinicopathological parameters of gastric tumors.
Methodology:
Tumor and adjacent normal tissue samples were collected from 62 patients with gastric cancer and subjected to immunohistochemistry with anti-HER-2/neu and -TOPIIa antibodies.
Results:
HER-2/neu (21.0%) and TOPIIa (80.6%) were expressed more commonly in gastric cancer than in normal gastric tissue (9.7% and 60.3%, respectively; p<0.05). However, there was no correlation between HER-2/neu and TOPIIa expression in gastric tumors. Further analysis showed a correlation between HER-2/neu expression and lymph node metastasis, distant metastases and tumor stage (p<0.05); TOPIIa was correlated with infiltration depth, distant metastases and tumor stage (p<0.05).
Conclusions:
HER-2/neu and TOPIIa are over expressed in gastric tumors and may promote disease progression. These proteins may therefore be useful as prognostic markers in evaluation of patients with gastric cancer.
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