Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hemorrhagic Stroke l: Introduction01:17

Hemorrhagic Stroke l: Introduction

A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...
Hemorrhagic Stroke ll: Pathophysiology01:29

Hemorrhagic Stroke ll: Pathophysiology

A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
Disorders of Hemostasis01:24

Disorders of Hemostasis

Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
Cytomegalovirus Disease01:27

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Predictors and Impact of Sulcal SAH after Mechanical Thrombectomy in Patients with Isolated M2 Occlusion.

AJNR. American journal of neuroradiology·2022
Same author

Infographic: Mid-term outcomes after the surgical treatment of atypical femoral fractures : minimum three-year follow-up.

The bone & joint journal·2021
Same author

Local Intra-arterial Thrombolysis during Mechanical Thrombectomy for Refractory Large-Vessel Occlusion: Adjunctive Chemical Enhancer of Thrombectomy.

AJNR. American journal of neuroradiology·2021
Same author

Association between time to treatment and functional outcomes according to the Diffusion-Weighted Imaging Alberta Stroke Program Early Computed Tomography Score in endovascular stroke therapy.

European journal of neurology·2019
Same author

Feasibility of Permanent Stenting with Solitaire FR as a Rescue Treatment for the Reperfusion of Acute Intracranial Artery Occlusion.

AJNR. American journal of neuroradiology·2017
Same author

Successful outcome with minimally invasive plate osteosynthesis for periprosthetic tibial fracture after total knee arthroplasty.

Orthopaedics & traumatology, surgery & research : OTSR·2016

Related Experiment Video

Updated: May 25, 2026

A Mouse Model of Hemorrhagic Transformation Induced by Acute Hyperglycemia Combined with Transient Focal Ischemia
09:35

A Mouse Model of Hemorrhagic Transformation Induced by Acute Hyperglycemia Combined with Transient Focal Ischemia

Published on: November 15, 2024

Is asymptomatic hemorrhagic transformation really innocuous?

J H Park1, Y Ko, W-J Kim

  • 1Department of Neurology, Dongguk University Gyeongju Hospital, Gyeongju, Korea.

Neurology
|January 28, 2012
PubMed
Summary

Asymptomatic hemorrhagic transformation (HT) in acute ischemic stroke patients doubles the odds of a worse 3-month outcome. This finding highlights the importance of monitoring even asymptomatic HT for long-term patient prognosis.

More Related Videos

Pre-Chiasmatic, Single Injection of Autologous Blood to Induce Experimental Subarachnoid Hemorrhage in a Rat Model
09:14

Pre-Chiasmatic, Single Injection of Autologous Blood to Induce Experimental Subarachnoid Hemorrhage in a Rat Model

Published on: June 18, 2021

Description of a Swine Infant Model of Volume-Controlled Hemorrhagic Shock
09:09

Description of a Swine Infant Model of Volume-Controlled Hemorrhagic Shock

Published on: November 3, 2023

Related Experiment Videos

Last Updated: May 25, 2026

A Mouse Model of Hemorrhagic Transformation Induced by Acute Hyperglycemia Combined with Transient Focal Ischemia
09:35

A Mouse Model of Hemorrhagic Transformation Induced by Acute Hyperglycemia Combined with Transient Focal Ischemia

Published on: November 15, 2024

Pre-Chiasmatic, Single Injection of Autologous Blood to Induce Experimental Subarachnoid Hemorrhage in a Rat Model
09:14

Pre-Chiasmatic, Single Injection of Autologous Blood to Induce Experimental Subarachnoid Hemorrhage in a Rat Model

Published on: June 18, 2021

Description of a Swine Infant Model of Volume-Controlled Hemorrhagic Shock
09:09

Description of a Swine Infant Model of Volume-Controlled Hemorrhagic Shock

Published on: November 3, 2023

Area of Science:

  • Neurology
  • Radiology
  • Clinical Medicine

Background:

  • Asymptomatic hemorrhagic transformation (HT) following acute ischemic stroke is common.
  • The long-term clinical significance of asymptomatic HT remains incompletely understood.
  • Previous studies suggest no immediate deterioration, but long-term impact is unclear.

Purpose of the Study:

  • To investigate the impact of asymptomatic HT on 3-month functional outcomes in acute ischemic stroke patients.
  • To determine if asymptomatic HT is clinically innocuous regarding long-term prognosis.
  • To quantify the association between asymptomatic HT and modified Rankin Scale (mRS) scores at 3 months.

Main Methods:

  • Analysis of a prospective stroke registry database of 1,618 patients hospitalized for ischemic stroke within 7 days of onset.
  • Inclusion criteria focused on patients with available 3-month mRS scores and exclusion of symptomatic HT or lack of specific MRI.
  • Calculation of odds ratios (OR) for asymptomatic HT associated with functional outcome, adjusted for relevant covariates.

Main Results:

  • Out of 1,412 eligible patients, 7.1% (100 patients) experienced asymptomatic HT.
  • Patients with asymptomatic HT were more likely to have cardioembolic stroke, receive thrombolytic therapy, heparin anticoagulation, and higher initial NIH Stroke Scale scores.
  • Crude and adjusted ORs for asymptomatic HT predicting a worse mRS score at 3 months were 2.94 and 1.90, respectively.

Conclusions:

  • Asymptomatic HT significantly increases the odds of a worse 3-month outcome in acute ischemic stroke patients.
  • The adjusted odds of a worse outcome are nearly doubled in patients with asymptomatic HT.
  • These findings suggest asymptomatic HT is not clinically innocuous and warrants careful consideration in stroke management.