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Updated: May 25, 2026

The Use of Pharmacological-challenge fMRI in Pre-clinical Research: Application to the 5-HT System
Published on: April 25, 2012
Comment on 5-HT and mechanisms of defence
S Wetzler1, G M Asnis, H M van Praag
1Department of Psychiatry, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY 10467, USA.
Abstract:
The paper by Deakin and Graeff is a thought-provoking tour-de-force. They propose a comprehensive theory about serotonin (5-hydroxytryptamine; 5-HT) and anxiety, covering much of the same literature which we previously reviewed (Kahn et al., 1988a). We certainly agree that there seems to be an association between 5-HT function and anxiety, but we take issue with several important aspects of Deakin and Graeff's hypothesis. We limit our comments to their discussion of anxiety and panic.
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