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Related Experiment Video

Updated: May 25, 2026

Less-Invasive Technique for Non-stabilized Mandibular Fracture in Mouse Models
04:13

Less-Invasive Technique for Non-stabilized Mandibular Fracture in Mouse Models

Published on: September 27, 2024

Composite mandibulectomy: a novel animal model.

Douglas R Sidell1, Tara Aghaloo, Sotirios Tetradis

  • 1Division of Head and Neck Surgery, David Geffen School of Medicine at UCLA, Los Angeles, California 90095-1624, USA. dsidell@mednet.ucla.edu

Otolaryngology--Head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
|January 28, 2012
PubMed
Summary

This study introduces a new rat model for creating segmental mandibular defects, crucial for studying reconstruction methods after conditions like osteoradionecrosis or tumor resection.

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Area of Science:

  • Oral and Maxillofacial Surgery
  • Surgical Research
  • Animal Models

Background:

  • Segmental mandibular defects arise from various conditions, including osteoradionecrosis, tumor resection, and fracture nonunion.
  • Reconstructing these defects is clinically significant, yet a standardized small-animal model is lacking.
  • Existing research necessitates a reliable model for studying en bloc mandibular defect repair.

Purpose of the Study:

  • To develop and describe a reliable rat model for creating en bloc segmental mandibular defects.
  • To provide a detailed surgical technique for segmental mandibulectomy in rats.
  • To establish a platform for investigating various reconstructive strategies for mandibular defects.

Main Methods:

  • Prospective analysis of survival operations in a rat model, approved by an Animal Research Oversight Committee.

Related Experiment Videos

Last Updated: May 25, 2026

Less-Invasive Technique for Non-stabilized Mandibular Fracture in Mouse Models
04:13

Less-Invasive Technique for Non-stabilized Mandibular Fracture in Mouse Models

Published on: September 27, 2024

  • Detailed stepwise surgical technique description, including intraoperative anatomy.
  • Documentation of postoperative management, potential pitfalls, and complications.

    • Main Results:

    • A total of 72 operations were performed by a single surgeon.
    • Recognized complications included 2 intraoperative and 9 postoperative issues.
    • Identified complications were orocutaneous fistulas (6), abscesses (2), seroma (1), and 4 fatalities.

    Conclusions:

    • The developed rat model reliably replicates en bloc segmental mandibular defects.
    • This model provides a valuable tool for research into mandibular defect reconstruction.
    • The model can be adapted for diverse research objectives in oral and maxillofacial surgery.