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04:38
A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats
Published on: May 22, 2019
Frontal infarcts and anxiety in stroke
Wai Kwong Tang1, Yangkun Chen, Jinyan Lu
1Department of Psychiatry, Shatin Hospital, Hong Kong SAR, China. tangwk@cuhk.edu.hk
Stroke
|January 28, 2012
Summary
This study found that right frontal lobe infarcts are linked to poststroke anxiety symptoms (PSA). These specific brain injuries are significant predictors of developing anxiety after a stroke.
Area of Science:
- Neurology
- Neuroscience
- Psychiatry
Background:
- Poststroke anxiety symptoms (PSA) are a common complication following cerebrovascular events.
- Understanding the neurobiological underpinnings of PSA is crucial for effective patient management.
Purpose of the Study:
- To investigate the association between the presence and location of frontal lobe infarcts and the occurrence of poststroke anxiety symptoms (PSA).
Main Methods:
- A cohort of 693 stroke patients was assessed for PSA using the Hospital Anxiety and Depression Scale.
- Brain magnetic resonance imaging (MRI) was utilized to identify the presence and precise location of acute and chronic infarcts, particularly within the frontal lobes.
Main Results:
- Patients experiencing PSA were significantly more likely to have experienced acute infarcts in the right frontal lobe compared to those without PSA.
- Multivariate analysis confirmed that right frontal lobe infarcts were an independent predictor of PSA, demonstrating a notable odds ratio of 4.44 (P=0.002).
Conclusions:
- The findings indicate a potential causal role for right frontal lobe acute infarcts in the development of poststroke anxiety symptoms.
- Targeting interventions or further research towards individuals with right frontal infarcts may help mitigate PSA development.
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