Controlled hemostasis in thoracic surgery using drugs with oxidized cellulose

Area of Science:

• Thoracic Surgery
• Surgical Hemostasis
• Oncology

Background:

• Extended resection procedures in thoracic surgery, particularly for advanced lung cancer, chest wall/mediastinum tumors, and complex inflammatory complications, are associated with significant perioperative blood loss exceeding 500 ml.
• High blood loss necessitates transfusions, increasing risks and potentially limiting treatment options for high-risk patients.

Purpose of the Study:

• To evaluate the efficacy of the local hemostatic agent Traumastem TAF (oxidized cellulose-based) in reducing perioperative bleeding during extensive thoracic surgeries.
• To assess the impact of minimized blood loss on the requirement for blood derivatives and the feasibility of performing complex procedures on high-risk individuals.

Main Methods:

• A retrospective analysis of patients undergoing extended resection procedures in thoracic surgery with expected blood loss >500 ml.
• Application of Traumastem TAF, a local hemostatic agent, during surgical procedures involving lung cancer (Stage III A post-neoadjuvant chemotherapy), chest wall/mediastinum tumors, and post-inflammatory thoracic complications requiring decortication and pleurectomy.

Main Results:

• Traumastem TAF effectively minimized perioperative blood loss in patients undergoing complex thoracic surgeries.
• Reduced blood loss led to a decreased need for blood derivative transfusions.
• The use of Traumastem TAF facilitated the completion of intended extensive resections, even in high-risk patient groups.

Conclusions:

• Local hemostatic agents like Traumastem TAF are valuable tools for managing perioperative bleeding in demanding thoracic surgical procedures.
• Reducing blood loss improves surgical outcomes, conserves blood resources, and expands treatment possibilities for complex thoracic conditions.