Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Obstructive Pulmonary Disease01:24

Chronic Obstructive Pulmonary Disease

COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Obstructive Pulmonary Disease-V: Management01:29

Chronic Obstructive Pulmonary Disease-V: Management

Managing Chronic Obstructive Pulmonary Disease (COPD) involves a multifaceted approach to reduce symptoms, prevent exacerbations, improve overall health status, and slow disease progression. Key strategies include lifestyle modifications, pharmacotherapy, supportive therapies, and, in some cases, surgery. Here is an overview of the primary COPD management strategies:
Smoking Cessation
Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.01:25

Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.

Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
Chronic Obstructive Pulmonary Disease-I: Introduction01:20

Chronic Obstructive Pulmonary Disease-I: Introduction

Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical phenotypes in α<sub>1</sub>-antitrypsin deficiency: a cluster analysis on EARCO data.

ERJ open research·2026
Same author

The acute respiratory response to blood-flow restriction resistance exercise in healthy adults: A randomized crossover trial.

Physiological reports·2026
Same author

Bronchoalveolar lavage for supporting acute cellular rejection in lung transplant recipients: A retrospective analysis.

JHLT open·2026
Same author

Real-time breath metabolomics as catalyst for personalized lung cancer diagnostics: prospective matched case-control trial (LUCAbreath).

Translational lung cancer research·2026
Same author

Metabolic effects following initiation of single-inhaler triple therapy in COPD: a prospective observational study.

Molecular medicine (Cambridge, Mass.)·2026
Same author

Relationship between hypoxic burden and cardiovascular effects in OSA - a post hoc analysis of an RCT.

Sleep medicine·2026

Related Experiment Video

Updated: May 25, 2026

Characterization of the Isolated, Ventilated, and Instrumented Mouse Lung Perfused with Pulsatile Flow
10:02

Characterization of the Isolated, Ventilated, and Instrumented Mouse Lung Perfused with Pulsatile Flow

Published on: April 29, 2011

Vascular dysfunction in chronic obstructive pulmonary disease: current evidence and perspectives.

Christian F Clarenbach1, Robert Thurnheer, Malcolm Kohler

  • 1Pulmonary Division, University Hospital of Zurich, Zurich, Switzerland. christian.clarenbach@usz.ch

Expert Review of Respiratory Medicine
|January 31, 2012
PubMed
Summary

Chronic obstructive pulmonary disease (COPD) is linked to serious systemic issues, including cardiovascular disease. Further research is needed to understand the connection and develop new treatments.

More Related Videos

Oxygenation-sensitive Cardiac MRI with Vasoactive Breathing Maneuvers for the Non-invasive Assessment of Coronary Microvascular Dysfunction
08:35

Oxygenation-sensitive Cardiac MRI with Vasoactive Breathing Maneuvers for the Non-invasive Assessment of Coronary Microvascular Dysfunction

Published on: August 17, 2022

Increasing Pulmonary Artery Pulsatile Flow Improves Hypoxic Pulmonary Hypertension in Piglets
08:08

Increasing Pulmonary Artery Pulsatile Flow Improves Hypoxic Pulmonary Hypertension in Piglets

Published on: May 11, 2015

Related Experiment Videos

Last Updated: May 25, 2026

Characterization of the Isolated, Ventilated, and Instrumented Mouse Lung Perfused with Pulsatile Flow
10:02

Characterization of the Isolated, Ventilated, and Instrumented Mouse Lung Perfused with Pulsatile Flow

Published on: April 29, 2011

Oxygenation-sensitive Cardiac MRI with Vasoactive Breathing Maneuvers for the Non-invasive Assessment of Coronary Microvascular Dysfunction
08:35

Oxygenation-sensitive Cardiac MRI with Vasoactive Breathing Maneuvers for the Non-invasive Assessment of Coronary Microvascular Dysfunction

Published on: August 17, 2022

Increasing Pulmonary Artery Pulsatile Flow Improves Hypoxic Pulmonary Hypertension in Piglets
08:08

Increasing Pulmonary Artery Pulsatile Flow Improves Hypoxic Pulmonary Hypertension in Piglets

Published on: May 11, 2015

Area of Science:

  • Pulmonary Medicine
  • Cardiovascular Medicine
  • Systemic Inflammation

Background:

  • Chronic obstructive pulmonary disease (COPD) is associated with systemic complications and comorbidities.
  • COPD increases the risk of cardiovascular disease, osteoporosis, cachexia, and skeletal muscle weakness.
  • Airflow limitation in COPD independently predicts cardiovascular events, suggesting a causal link.

Purpose of the Study:

  • To explore the pathomechanisms underlying the association between COPD and cardiovascular disease.
  • To evaluate the current evidence for a causal relationship between COPD and vascular dysfunction.
  • To highlight the need for well-designed studies to identify novel therapeutic and preventive strategies.

Main Methods:

  • Review of large prospective cohort studies.
  • Analysis of predictors for cardiovascular events in COPD patients.
  • Exploration of proposed pathomechanisms including systemic inflammation, oxidative stress, hypoxia, and sympathetic activation.

Main Results:

  • Degree of airflow limitation is an independent predictor of fatal and nonfatal cardiovascular events.
  • Proposed pathomechanisms linking COPD to vascular dysfunction are systemic inflammation, oxidative stress, hypoxia, and sympathetic activation.
  • Current evidence for a causal relationship between COPD and vascular dysfunction is insufficient.

Conclusions:

  • The association between COPD and cardiovascular disease requires further investigation into underlying pathomechanisms.
  • More robust data from well-designed studies are essential.
  • Understanding these links may lead to novel therapeutic and preventive approaches for COPD patients.