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A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Left Lung Orthotopic Transplantation in a Juvenile Porcine Model for ESLP
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Published on: February 14, 2022

Selecting lung transplant candidates: where do current guidelines fall short?

Jaime L Hook1, David J Lederer

  • 1Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, USA.

Expert Review of Respiratory Medicine
|January 31, 2012
PubMed
Summary

Lung transplant candidate selection needs improvement. New factors like frailty may help predict early complications and death, improving patient outcomes and lung transplant success rates.

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Orthotopic Left Lung Transplantation in Rats
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Left Lung Orthotopic Transplantation in a Juvenile Porcine Model for ESLP
06:55

Left Lung Orthotopic Transplantation in a Juvenile Porcine Model for ESLP

Published on: February 14, 2022

Orthotopic Left Lung Transplantation in Rats
08:22

Orthotopic Left Lung Transplantation in Rats

Published on: July 3, 2025

Area of Science:

  • Medicine
  • Transplantation Surgery
  • Pulmonology

Background:

  • Lung transplantation is limited by donor organ availability, necessitating careful patient selection.
  • Despite selection criteria, 20% of lung transplant recipients experience mortality within the first year post-procedure.
  • Current selection guidelines rely on expert opinion and limited case series, potentially missing high-risk individuals.

Purpose of the Study:

  • To review current lung transplant candidate selection guidelines.
  • To propose the investigation of novel extrapulmonary factors for improved risk prediction.
  • To enhance the identification of candidates likely to benefit from lung transplantation and avoid early complications.

Main Methods:

  • Review of existing literature and guidelines for lung transplant candidate selection.
  • Discussion of the limitations of current selection criteria.
  • Proposal for incorporating extrapulmonary factors like frailty and sarcopenia into risk assessment.

Main Results:

  • Current lung transplant selection criteria are primarily based on expert opinion and small studies.
  • A significant proportion of lung transplant recipients face early mortality, indicating a need for better risk stratification.
  • Extrapulmonary factors such as frailty and sarcopenia are proposed as potentially valuable additions to selection criteria.

Conclusions:

  • Improved prediction of early complications and mortality after lung transplantation is crucial.
  • Incorporating novel factors like frailty and sarcopenia could refine candidate selection processes.
  • Enhanced selection may lead to better survival benefits and outcomes for lung transplant recipients.