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Updated: May 25, 2026
Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
Published on: August 28, 2015
Preparation of novel solid lipid microparticles loaded with gentamicin and its evaluation in vitro and in vivo
Emmanuel Chukwuebuka Umeyor1, Franklin Chimaobi Kenechukwu, John Dike Ogbonna
1School of Pharmacy, University of Nigeria, Nsukka 410001, Nigeria.
Objective:
To formulate and evaluate solid-reversed-micellar-solution (SRMS)-based solid lipid microparticles (SLMs) for intramuscular administration of gentamicin.
Methods:
SRMS formulated with Phospholipon® 90G and Softisan® 154 were used to prepare gentamicin-loaded SLMs. Characterizations based on size and morphology, stability and encapsulation efficiency (EE%) were carried out on the SLMs. In vitro release of gentamicin from the SLMs was performed in phosphate buffer while in vivo release studies were conducted in rats.
Results:
Maximum EE% of 90.0, 91.6 and 83.0% were obtained for SLMs formed with SRMS 1:1, 1:2 and 2:1, respectively. Stable, spherical and smooth SLMs of size range 9.80 ± 1.46 µm to 33.30 ± 6.42 µm were produced. The release of gentamicin in phosphate buffer varied widely with the lipid contents. Moreover, significant (p < 0.05) amount of gentamicin was released in vivo from the SLMs.
Conclusion:
SRMS-based SLMs would likely offer a reliable means of delivering gentamicin intramuscularly.
