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Updated: May 25, 2026
08:22
Orthotopic Left Lung Transplantation in Rats
Published on: July 3, 2025
New developments in treatment after lung transplantation.
Christian Benden1, Lara Danziger-Isakov, Albert Faro
1Division of Pulmonary Medicine, University Hospital Zurich, Raemistr 100, CH-8091 Zurich, Switzerland. christian_benden@yahoo.de
Current Pharmaceutical Design
|January 31, 2012
Summary
Lung transplantation survival rates exceed 70% due to immunosuppressive agents. This review details immunosuppression strategies, infection management, and chronic lung allograft dysfunction treatments for lung transplant recipients.
Area of Science:
- Medicine
- Surgery
- Immunology
Background:
- Lung transplantation is a viable treatment for end-stage lung disease in adults and children.
- Recent advancements have improved survival rates and functional status in lung transplant recipients.
Purpose of the Study:
- To review current immunosuppressive strategies for lung transplantation.
- To discuss infection prevention and treatment in lung transplant recipients.
- To explore management options for chronic lung allograft dysfunction.
Main Methods:
- Review of current literature on immunosuppression, infections, and chronic lung allograft dysfunction in lung transplantation.
- Analysis of evidence supporting various immunosuppressive agents and therapeutic approaches.
Main Results:
- Lung transplantation offers >70% 5-year survival with good functional outcomes.
- Immunosuppressive agents play crucial roles in induction, maintenance, and rescue therapy.
- Infections and chronic lung allograft dysfunction remain significant challenges.
Conclusions:
- Optimized immunosuppression and infection management are key to successful lung transplantation.
- Further research is needed to effectively treat chronic lung allograft dysfunction.
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