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Hepatitis C virus infection in patients with tuberculosis in Central Brazil

N R S Reis1, C L R Lopes, S A Teles

  • 1Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás, Goiânia, Goás, Brazil.

The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease
|January 31, 2012
PubMed

Insights

In Brazil, 7.5% of tuberculosis patients had hepatitis C virus (HCV) infection, with age, drug use, and HIV status as key risk factors. Integrated HIV and HCV screening can improve tuberculosis management.

Area of Science:

  • Infectious Diseases
  • Public Health
  • Virology

Background:

  • Tuberculosis (TB) and viral infections like hepatitis C virus (HCV) and human immunodeficiency virus (HIV) often coexist.
  • Understanding the prevalence and risk factors of HCV and HIV in TB patients is crucial for effective public health strategies.

Purpose of the Study:

  • To determine the prevalence of HCV infection, associated risk factors, HCV genotypes/subtypes, viral load, and HIV status among tuberculosis patients in Central Brazil.
  • To assess the potential benefits of integrated HIV and HCV screening in TB patient management.

Main Methods:

  • A cross-sectional study was conducted with 402 patients undergoing tuberculosis treatment in Goiânia, Brazil.
  • Data collected included HCV and HIV prevalence, risk factors (age, injecting drug use), HCV RNA levels, and HCV genotyping (LiPA and phylogenetic analysis).

Main Results:

  • Hepatitis C virus (HCV) prevalence was 7.5% and human immunodeficiency virus (HIV) prevalence was 27.6%.
  • Injecting drug use, age, and HIV status were independently associated with HCV infection. Two-thirds of HCV-infected patients were also HIV-positive.
  • HCV genotypes 1 and 3 were identified, with subtypes 1a, 1b, and 3a detected. HCV RNA levels were slightly higher in co-infected patients.

Conclusions:

  • Integrated screening for HIV and HCV in tuberculosis patients is recommended.
  • Such screening can significantly impact tuberculosis management and treatment outcomes.
Abstract

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