Related Experiment Videos
Trypanosoma cruzi: calcium ion movement during internalization in host HeLa cells
A Osuna1, S Castanys, M N Rodriguez-Cabezas
1Institute of Biotechnology, University of Granada, Science Faculty Campus Fuente Nueva C/Severo Ochoa, Spain.
International Journal for Parasitology
|August 1, 1990
Abstract:
The role of cytosolic Ca2+ and cytoplasmic calcium movement during the parasitization of HeLa cells by T. cruzi were studied. The level of calcium in parasitized cells increased compared to the control cells. Our experiments demonstrate that this cytosolic calcium originates from the release of the intracellular calcium deposits, especially from the mitochondria of the host cell. The parasitization rates decreased after the cells were treated with drugs to increase the cytosolic Ca2+ levels to inhibit the host-cell calmodulin.