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Ambulatory arterial stiffness indices and target organ damage in hypertension

Manuel Angel Gómez-Marcos1, José Ignacio Recio-Rodríguez, Ma Carmen Patino-Alonso

  • 1Primary Care Research Unit, La Alamedilla Health Centre, Salamanca, Spain, REDIAPP. magomez@usal.es

BMC Cardiovascular Disorders
|January 31, 2012
PubMed

Insights

Arterial stiffness index (AASI) and home arterial stiffness index (HASI) show varying correlations with organ damage in hypertension. AASI best predicts vascular damage, while HASI-BPVR is linked to renal function.

Area of Science:

  • Cardiology
  • Nephrology
  • Vascular Medicine

Background:

  • Hypertension is a major risk factor for cardiovascular and renal diseases.
  • Arterial stiffness is an indicator of vascular aging and cardiovascular risk.
  • Assessing arterial stiffness is crucial for managing hypertensive patients.

Purpose of the Study:

  • To compare the correlation of two arterial stiffness parameters, AASI and HASI, with vascular, cardiac, and renal damage in hypertensive individuals.
  • To determine which arterial stiffness measure is a better predictor of target organ damage.

Main Methods:

  • A cross-sectional study included 258 hypertensive patients.
  • Arterial stiffness was assessed using AASI (24-hour BP recordings) and HASI (home BP recordings).
  • Vascular damage (IMT, PWV, ABI), cardiac damage (VDP, Novacode index), and renal damage (GFR, microalbuminuria) were evaluated.

Main Results:

  • AASI and HASI-BPVR correlated negatively with GFR.
  • Carotid IMT and PWV positively correlated with AASI and its variants, but not HASI.
  • AASI and Awake-AASI showed significant associations with IMT, PWV, and ABI after adjustments.

Conclusions:

  • AASI and Awake-AASI are strongly associated with vascular damage markers (IMT, PWV, ABI) in hypertensive patients.
  • HASI-BPVR demonstrated an association with renal function (GFR).
  • These findings highlight the utility of different arterial stiffness parameters in assessing organ-specific damage in hypertension.
Abstract

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