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Updated: May 25, 2026

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
Published on: June 3, 2020
Reserve, brain changes, and decline
1Aberdeen Royal Infirmary, Department of Bio-Medical Physics, NHS-Grampian and the University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, Scotland, UK. r.staff@abdn.ac.uk
Abstract:
Reserve refers to the brain's ability to cope with increasing damage. There is no direct measure of reserve, but it is commonly reflected in the literature by proxies such as brain volume, head size, education, occupation, socioeconomic status, and mental and physical engagement. This article provides an overview of the concepts and applications being used to explore reserve, and discusses how these empiric proxies of reserve, their hypothesized biological mechanisms, and the apparent protection from age-related disease are connected.
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