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Reduction in Left Ventricular Wall Stress and Improvement in Function in Failing Hearts using Algisyl-LVR
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Left ventricular noncompaction: a 25-year odyssey

Timothy E Paterick1, Matt M Umland, M Fuad Jan

  • 1Aurora Cardiovascular Services, Aurora Sinai/Aurora St. Luke's Medical Centers, University of Wisconsin School of Medicine and Public Health, 2801 W. Kinnickinnic River Parkway #845, Milwaukee, WI 53215, USA. publishing15@aurora.org

Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography
|January 31, 2012
PubMed

Insights

Left ventricular noncompaction (LVNC) is a heart muscle disease with varied symptoms and risks. Advances in imaging like echocardiography and cardiac MRI enhance diagnosis and understanding of this condition.

Area of Science:

  • Cardiology
  • Genetics
  • Medical Imaging

Background:

  • Left ventricular noncompaction (LVNC) is a primary cardiomyopathy.
  • It can be sporadic or familial, often with autosomal dominant inheritance.
  • Clinical presentations range from asymptomatic to severe heart failure, arrhythmias, and sudden cardiac death.

Purpose of the Study:

  • To summarize the current understanding of LVNC.
  • To highlight diagnostic modalities and their advancements.
  • To underscore the progress in comprehending this heterogeneous cardiac condition.

Main Methods:

  • Echocardiography is the primary diagnostic tool.
  • Cardiac magnetic resonance imaging (CMR) aids in staging disease severity.
  • Research integrates embryology, imaging, and genetics.

Main Results:

  • Echocardiography reveals a thick, bilayered myocardium with prominent trabeculations and deep recesses.
  • CMR improves disease staging and prediction of adverse events.
  • Increased awareness and improved imaging technologies are enhancing LVNC diagnosis.

Conclusions:

  • LVNC is a complex cardiomyopathy with significant clinical implications.
  • Advancements in echocardiography and CMR have revolutionized its diagnosis and management.
  • Ongoing research in genetics and embryology continues to deepen our understanding of LVNC's heterogeneity.

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