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Related Concept Videos

Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
Aortic Regurgitation I: Introduction01:15

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Mitral Regurgitation I: Introduction01:20

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Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...

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Related Experiment Video

Updated: May 25, 2026

Reduction in Left Ventricular Wall Stress and Improvement in Function in Failing Hearts using Algisyl-LVR
07:24

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Published on: April 8, 2013

Left ventricular noncompaction: a 25-year odyssey.

Timothy E Paterick1, Matt M Umland, M Fuad Jan

  • 1Aurora Cardiovascular Services, Aurora Sinai/Aurora St. Luke's Medical Centers, University of Wisconsin School of Medicine and Public Health, 2801 W. Kinnickinnic River Parkway #845, Milwaukee, WI 53215, USA. publishing15@aurora.org

Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography
|January 31, 2012
PubMed
Summary
This summary is machine-generated.

Left ventricular noncompaction (LVNC) is a heart muscle disease with varied symptoms and risks. Advances in imaging like echocardiography and cardiac MRI enhance diagnosis and understanding of this condition.

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Last Updated: May 25, 2026

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Published on: April 8, 2013

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Area of Science:

  • Cardiology
  • Genetics
  • Medical Imaging

Background:

  • Left ventricular noncompaction (LVNC) is a primary cardiomyopathy.
  • It can be sporadic or familial, often with autosomal dominant inheritance.
  • Clinical presentations range from asymptomatic to severe heart failure, arrhythmias, and sudden cardiac death.

Purpose of the Study:

  • To summarize the current understanding of LVNC.
  • To highlight diagnostic modalities and their advancements.
  • To underscore the progress in comprehending this heterogeneous cardiac condition.

Main Methods:

  • Echocardiography is the primary diagnostic tool.
  • Cardiac magnetic resonance imaging (CMR) aids in staging disease severity.
  • Research integrates embryology, imaging, and genetics.

Main Results:

  • Echocardiography reveals a thick, bilayered myocardium with prominent trabeculations and deep recesses.
  • CMR improves disease staging and prediction of adverse events.
  • Increased awareness and improved imaging technologies are enhancing LVNC diagnosis.

Conclusions:

  • LVNC is a complex cardiomyopathy with significant clinical implications.
  • Advancements in echocardiography and CMR have revolutionized its diagnosis and management.
  • Ongoing research in genetics and embryology continues to deepen our understanding of LVNC's heterogeneity.