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Updated: May 25, 2026

Microsatellite DNA Genotyping and Flow Cytometry Ploidy Analyses of Formalin-fixed Paraffin-embedded Hydatidiform Molar Tissues
Published on: October 20, 2019
Prenatal diagnosis of a trisomy 7/trisomy 13 mosaicism
Karin Huijsdens-van Amsterdam1, Daniela Qcm Barge-Schaapveld, Inge B Mathijssen
1Department of Clinical Genetics, Academic Medical Center, Amsterdam, The Netherlands. k.huijsdens@amc.uva.nl.
Abstract:
Double aneuploidy mosaicism of two different aneuploidy cell lines is rare. We describe for the first time a double trisomy mosaicism, involving chromosomes 7 and 13 in a fetus presenting with multiple congenital anomalies. No evidence for chimerism was found by DNA genotyping. The origin of both trisomies are consistent with isodisomy of maternal origin. Therefore, it is most likely that the double trisomy mosaicism arose from two independent events very early in embryonic development. The trisomy 7 and 13 cells were shown to be of maternal origin.
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