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Site-Targeted Drug Delivery Systems: Polymeric Carriers

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

Modified-Release Drug Delivery Systems: Site-Targeted

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.

Drug Delivery Systems: Different Types

Drug Delivery Systems: Different Types

Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...

Drug Delivery: Overview

Drug Delivery: Overview

The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the gastrointestinal...

Modified-Release Drug Delivery Systems: Overview

Modified-Release Drug Delivery Systems: Overview

Modified-release dosage forms are designed to address the limitations of drugs with short biological half-lives. These forms maintain stable therapeutic drug concentrations over extended periods, reducing the need for frequent dosing. A consistent drug level helps minimize peak-trough fluctuations, which can reduce adverse effects, lower the risk of drug resistance, and improve overall treatment effectiveness.One common type of modified-release form is the extended-release (ER) formulation. ER...

Modified-Release Drug Delivery Systems: Classification

Modified-Release Drug Delivery Systems: Classification

Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...

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Related Experiment Video

Updated: May 25, 2026

Manufacture and Drug Delivery Applications of Silk Nanoparticles

Manufacture and Drug Delivery Applications of Silk Nanoparticles

Published on: October 8, 2016

Virus-based nanocarriers for drug delivery.

Yujie Ma¹, Roeland J M Nolte, Jeroen J L M Cornelissen

¹Group of Biomolecular Nanotechnology, MESA(+) Institute for Nanotechnology, University of Twente, P.O. Box 217, 7500 AE Enschede, The Netherlands.

Advanced Drug Delivery Reviews

|January 31, 2012

Summary

Virus-like particles (VLPs) are promising natural nanocarriers for drug delivery. Modifications enhance their biocompatibility, solubility, and uptake, paving the way for advanced nanomedicine applications.

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Published on: February 8, 2017

Area of Science:

Biomedical Engineering
Nanotechnology
Drug Delivery Systems

Background:

Natural biological building blocks offer novel nanocarrier platforms for medicine.
Protein cage structures, specifically virus-like particles (VLPs), are explored for drug packaging and targeted delivery.
Existing nanocarriers face challenges in biocompatibility, solubility, and efficient cellular uptake.

Purpose of the Study:

To summarize the application of virus-like particles (VLPs) as nanocarriers for drug delivery.
To highlight the potential of chemically and genetically modified VLPs for advanced therapeutic applications.
To emphasize the need for comprehensive evaluation of VLP-based nanocarriers.

Main Methods:

Review of literature on virus-like particles (VLPs) for drug delivery.
Analysis of chemical and genetic modification strategies for VLPs.
Discussion of requirements for effective nanocarrier systems (biocompatibility, solubility, uptake efficiency).

Main Results:

Virus-like particles (VLPs) demonstrate versatility for drug packaging and targeted delivery.
Modifications on VLP surfaces and cavities enable the creation of materials meeting key drug delivery requirements.
VLPs offer potential for improved biocompatibility, solubility, and cellular uptake compared to conventional carriers.

Conclusions:

Virus-like particles (VLPs) represent a promising platform for revolutionizing drug delivery and nanomedicine.
Further evaluation of toxicity, bio-distribution, and immunology is crucial for clinical translation.
Optimized VLP-based nanocarriers hold significant potential for enhancing therapeutic efficacy.