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Updated: May 25, 2026

An In Ovo Model for Testing Insulin-mimetic Compounds
Published on: April 23, 2018
Insulin signaling - mathematical modeling comes of age
Elin Nyman1, Gunnar Cedersund, Peter Strålfors
1Department of Clinical and Experimental Medicine, University of Linköping, SE58185 Linköping, Sweden.
Abstract:
Signaling pathways that only a few years ago appeared simple and understandable, albeit far from complete, have evolved into very complex multi-layered networks of cellular control mechanisms, which in turn are integrated in a similarly complex whole-body level of control mechanisms. This complexity sets limits for classical biochemical reasoning, such that a correct and complete analysis of experimental data while taking the full complexity into account is not possible. In this Opinion we propose that mathematical modeling can be used as a tool in insulin signaling research, and we demonstrate how recent developments in modeling - and the integration of modeling in the experimental process - provide new possibilities to approach and decipher complex biological systems more efficiently.
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