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Processing of Bronchoalveolar Lavage Fluid and Matched Blood for Alveolar Macrophage and CD4+ T-cell Immunophenotyping and HIV Reservoir Assessment
Published on: June 23, 2019
HIV and asthma, is there an association?
Jessica A Kynyk1, Jonathan P Parsons, Michael F Para
1The Ohio State University, Department of Internal Medicine, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, 201 Davis Heart & Lung Research Institute, 473 West 12th Avenue, Columbus, OH 43210, USA. Jessica.Kynyk@osumc.edu
Respiratory Medicine
|January 31, 2012
Summary
This review explores the link between HIV infection and asthma. While HIV patients often have respiratory issues, more research is needed to confirm if asthma and airway hyper-responsiveness are more common post-HAART.
Area of Science:
- Pulmonology
- Infectious Diseases
- Immunology
Background:
- HIV infection is associated with various pulmonary complications.
- Immune dysregulation in HIV may influence airway conditions.
- The advent of Highly Active Antiretroviral Therapy (HAART) has altered the landscape of HIV-related diseases.
Purpose of the Study:
- To investigate the association between asthma and airway hyper-responsiveness in individuals with HIV infection.
- To analyze changes in pulmonary symptoms and immune markers related to HIV.
- To compare findings from the pre-HAART era with the post-HAART era.
Main Methods:
- Literature review of HIV-associated pulmonary diseases, symptoms, and immune changes.
- Analysis of studies comparing pre-HAART and post-HAART data.
- Examination of pulmonary function tests and serum IgE levels in HIV-infected individuals.
Main Results:
- HIV-seropositive individuals frequently report respiratory complaints.
- Pulmonary function and serum IgE changes are observed in HIV infection, persisting post-HAART.
- An increased prevalence of asthma has been reported in HIV-seropositive children on HAART.
Conclusions:
- The spectrum of HIV-associated pulmonary disease has evolved with HAART introduction.
- Limited current data exists to definitively establish increased asthma or airway hyper-responsiveness in HIV-positive individuals on HAART.
- Further research is warranted to clarify the relationship between HIV, HAART, and asthma.
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