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Updated: May 25, 2026

A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting
Published on: January 12, 2018
Life course variation in the relation between maternal marital status and preterm birth
Abdulrahman M El-Sayed1, Melissa Tracy, Sandro Galea
1Department of Epidemiology, Columbia University, 722 W. 168th Street, New York, NY 10032, USA. ame2145@columbia.edu
Purpose:
Maternal marriage is protective against preterm birth (PTB), whereas advanced maternal age is associated with increased PTB risk. Because relations between social factors and health may vary during the life course, we assessed how the relation between marital status and PTB risk may change with maternal age.
Methods:
We assessed the interaction between marital status and maternal age as a determinant of PTB among all live singleton births in Michigan between 1995 and 2006. We also fit stratified models by race. We calculated absolute differences in predicted PTB as well as odds ratios of PTB by marital status for each age group.
Results:
In adjusted models, there was a significant interaction (p(interaction)<.001) between marital status and maternal age. The predicted probability of PTB by marital status was marginally different among mothers ages 20-25 years (absolute difference of 1.5%); this difference was substantially greater (3.9% or greater) after 31 years of age. Odds of PTB followed a similar trajectory. Findings were similar among black and white mothers.
Conclusions:
The relationship between marriage and PTB may vary with maternal age suggesting that the influence of social factors on risk for adverse birth outcomes may differ through the maternal life trajectory. We discuss plausible explanations for these findings.
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