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Atypical meningiomas--a case series
Marko Andric1, Shreya Dixit, Arvind Dubey
1Department of Neurosurgery, Royal Hobart Hospital, GPO Box 1061L, Hobart 7001, Tasmania, Australia.
Clinical Neurology and Neurosurgery
|January 31, 2012
Summary
Atypical meningiomas (grade 2) exhibit unpredictable behavior and prognosis. This study highlights the challenging nature of these rare tumors, with significant recurrence and metastasis observed.
Area of Science:
- Neurosurgery
- Oncology
- Pathology
Background:
- Meningiomas are tumors arising from the meninges.
- Atypical meningiomas (WHO grade 2) represent a subset with variable behavior.
- Accurate classification and understanding of atypical meningiomas are crucial for patient management.
Purpose of the Study:
- To analyze the clinical behavior and outcomes of atypical meningiomas.
- To characterize the prognosis and recurrence patterns of these tumors.
- To underscore the challenges in managing atypical meningiomas.
Main Methods:
- Retrospective review of 169 meningioma surgeries over 19 years.
- Identification of 9 atypical meningioma cases (WHO 2007 classification).
- Analysis of patient demographics, follow-up duration, recurrence, and survival data.
Main Results:
- Atypical meningiomas constituted 5.3% of all operated meningiomas.
- Average patient age was 51 years, with a median follow-up of 103 months.
- Five patients died between 38-219 months post-diagnosis; one experienced 12 recurrences, and two developed metastases.
Conclusions:
- Atypical meningiomas demonstrate highly unpredictable behavior and prognosis.
- The findings emphasize the difficult and challenging nature of managing these tumors.
- Further research is warranted to improve outcomes for patients with atypical meningiomas.
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