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The vasohibin family: Novel regulators of angiogenesis

Yasufumi Sato1

  • 1Department of Vascular Biology, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryo-machi, Sendai 980-8575, Japan. y-sato@idac.tohoku.ac.jp

Vascular Pharmacology
|January 31, 2012
PubMed

Angiogenesis is thought to be regulated by the local balance between angiogenesis stimulators and angiogenesis inhibitors. A number of endogenous regulators of angiogenesis have been found in the body. We recently isolated vasohibin-1 (VASH1) as a negative feedback regulator of angiogenesis produced by endothelial cells, and VASH2 as a homologue of VASH1 thereafter. We found that VASH1 was expressed in endothelial cells to terminate angiogenesis, whereas VASH2 promoted angiogenesis, in the mouse model of angiogenesis. This mini-review will focus on the vasohibin family in relation to the regulation of angiogenesis.

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