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Related Concept Videos

Antiasthma Drugs: Leukotriene Modifiers01:19

Antiasthma Drugs: Leukotriene Modifiers

Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
Drugs Used in Lower Respiratory Disorders: Overview01:17

Drugs Used in Lower Respiratory Disorders: Overview

Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids01:25

Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids

Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Drugs Used in Upper Respiratory Disorders: Overview01:16

Drugs Used in Upper Respiratory Disorders: Overview

Upper respiratory tract disorders, including viral infections and allergic rhinitis, cause significant discomfort and disrupt daily life. Managing these conditions involves a variety of drugs, such as antihistamines, intranasal steroids, decongestants, antitussives, expectorants, and mucolytics. Specific examples of drugs in each category are provided.
Antihistamines (e.g., Benadryl) block histamines from binding. Histamines are chemicals released during an allergic reaction in the body. As a...

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Related Experiment Video

Updated: May 25, 2026

Real-time Imaging of Leukotriene B4 Mediated Cell Migration and BLT1 Interactions with &beta;-arrestin
13:45

Real-time Imaging of Leukotriene B4 Mediated Cell Migration and BLT1 Interactions with β-arrestin

Published on: December 23, 2010

Leukotriene Inhibitors in Sinusitis.

John W Steinke1, Joshua L Kennedy

  • 1Asthma and Allergic Diseases Center, University of Virginia Health System, Charlottesville, VA, 22908-1355, USA, js3ch@virginia.edu.

Current Infectious Disease Reports
|January 31, 2012
PubMed
Summary

Leukotrienes contribute to allergic reactions and chronic sinusitis. This review explores leukotriene antagonists and synthesis inhibitors for treating chronic sinusitis, including potential off-label drug uses.

Area of Science:

  • Immunology
  • Pharmacology
  • Otolaryngology

Background:

  • Leukotrienes are key mediators of allergic reactions.
  • Emerging evidence implicates leukotrienes in chronic sinusitis, especially eosinophilic subtypes.
  • Leukotrienes include cysteinyl leukotrienes and leukotriene B(4), acting via specific receptors.

Purpose of the Study:

  • To review the role of leukotrienes in chronic sinusitis.
  • To evaluate the rationale for using leukotriene antagonists versus synthesis inhibitors.
  • To discuss potential off-label therapeutic strategies modulating leukotriene action.

Main Methods:

  • Literature review focusing on leukotriene involvement in chronic sinusitis.
  • Analysis of pharmaceutical approaches targeting leukotriene pathways.

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  • Discussion of therapeutic options and their mechanisms of action.

    • Main Results:

    • Two main drug classes target leukotrienes: cysteinyl type 1 receptor antagonists and 5-lipoxygenase inhibitors.
    • These drugs are approved for allergic diseases and relevant to chronic sinusitis treatment.
    • Off-label medications may also modulate leukotriene activity.

    Conclusions:

    • Leukotriene modulation is a viable therapeutic strategy for chronic sinusitis.
    • The choice between antagonists and synthesis inhibitors depends on specific disease characteristics.
    • Further research into off-label uses could expand treatment options.