[Fatal pneumonitis during low-dose methotrexate treatment]
1Institut für Rechtsmedizin, Abteilung Forensische Medizin, Universität Zürich, Winterthurerstr. 190/52, CH-8057, Zürich, Schweiz, viktor.martos@irm.uzh.ch.
Abstract:
We present the case of a 71 year old Swiss woman with a symptomatic rheumatic arthritis whose rheumatologist started a therapy with methotrexate. While the symptoms disappeared completely, the woman died about two months later suddenly. By then she got a cumulative dose of 160 mg. The forensic post-mortem examination showed a fibrosing alveolitis. If respiratory symptoms appear under methotrexat regimen therapy, immediate stopping the medication could be life-saving. In accordance to the chest x-ray a cortisone therapy can be established.
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