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Transcutaneous Assessment of Renal Function in Conscious Rodents
Published on: March 26, 2016
Trends in estimated kidney function: the FINRISK surveys.
Auni Juutilainen1, Helena Kastarinen, Riitta Antikainen
1Institute of Clinical Medicine/Internal Medicine, Universityof Eastern Finland, and Department of Medicine, Kuopio University Hospital, P.O.B. 1777, 70211 Kuopio, Finland. auni.juutilainen@kuh.fi
European Journal of Epidemiology
|January 31, 2012
Summary
Estimated glomerular filtration rate (eGFR) declined in adults aged 25-74 between 2002 and 2007. Chronic kidney disease (CKD) stage 3-5 prevalence increased in women, concurrent with rising diabetes and obesity.
Area of Science:
- Nephrology
- Epidemiology
- Public Health
Background:
- Chronic kidney disease (CKD) affects millions globally, with increasing prevalence linked to metabolic risk factors.
- Understanding temporal trends in kidney function is crucial for public health interventions.
Purpose of the Study:
- To evaluate changes in estimated glomerular filtration rate (eGFR) and CKD prevalence between 2002 and 2007 in adults aged 25-74.
- To identify demographic and clinical factors associated with these trends.
Main Methods:
- Cross-sectional analysis of population survey data from 2002 and 2007.
- Calculation of eGFR using the CKD-EPI equation.
- Analysis of CKD stage 3-5 prevalence (eGFR < 60 mL/min/1.73 m²) stratified by sex and age.
Main Results:
- Mean eGFR significantly decreased across all age groups and both genders from 2002 to 2007.
- Prevalence of CKD stage 3-5 increased in women (1.8% to 3.1%, P=0.017) but not in men.
- Overall CKD stage 3-5 prevalence was higher in 2007 vs. 2002 (OR 1.59, 95% CI 1.22–2.08), associated with increased waist circumference and diabetes mellitus.
Conclusions:
- A significant decline in mean eGFR and an increase in advanced CKD stages were observed between 2002 and 2007.
- The rise in CKD, particularly in women, coincided with increasing rates of obesity and diabetes mellitus.
- These findings highlight the need for targeted public health strategies to address kidney disease progression.
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