External beam radiation therapy for PTFE dialysis grafts: a pilot study
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Updated: May 25, 2026
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Prabir Roy-Chaudhury1, Heather J Duncan, Darryl Zuckerman
1Dialysis Vascular Access Research Group, Division of Nephrology, University of Cincinnati, Cincinnati, OH 45267-0585, USA. prabir.roychaudhury@uc.edu
Purpose:
The aim of this study was to identify the effects of external beam radiation on PTFE dialysis graft dysfunction.
Methods:
Seven patients who underwent PTFE dialysis graft angioplasty were randomized to receive either two 8 Gy doses of external beam radiation or no radiation. The primary endpoint was time to graft thrombosis with a secondary endpoint of time to first intervention.
Results:
There was no statistically significant difference between the two groups in either of the endpoints, although grafts in the radiation group had a shorter time to thrombosis or intervention.
Conclusions:
Our results demonstrate technical feasibility for use of external beam radiation in the setting of dialysis vascular access graft dysfunction. Larger randomized studies are required to identify whether there is a clinical benefit from this intervention.
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