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Updated: May 25, 2026

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells
Published on: April 7, 2017
t(3;8) as the sole chromosomal abnormality in a myoepithelial carcinoma ex pleomorphic adenoma: a putative
Diana Bell1, Jeffrey N Myers, Pulivarthi H Rao
1Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Background:
Carcinoma ex pleomorphic adenoma (Ca ex-PA) is defined as a carcinoma arising from a primary (de novo) or recurrent benign pleomorphic adenoma (PA).
Methods:
We present a parotid myoepithelial carcinoma ex pleomorphic adenoma in a 38-year-old man with a t(3;8)(p21;q13) as the only chromosomal alteration by cytogenetic and spectral karyotypic analysis (SKY).
Results:
The finding of this translocation in a subset of PA and in the present case suggests a critical role for this event in the malignant transformation of PA.
Conclusions:
Collectively, both the cytogenetic and the molecular studies suggest the concept that PA lacking alterations pursue a benign behavior, whereas those with the t(3;8) translocation may progress to carcinoma.
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