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Updated: May 25, 2026

Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity
Published on: March 16, 2018
Doxycycline treatment of otosyphilis with hearing loss
Verajit Chotmongkol1, Kittisak Sawanyawisuth, Kwanchanok Yimtae
1Department of Medicine, Faculty of Medicine, 123 Mitraparp Road, Khon Kaen 40002, Thailand.
Objectives:
The recommended treatment of otosyphilis is intravenous penicillin therapy. The response rate varied between 23% and 31%. This treatment needs hospitalisation and is costly, inconvenient and time consuming. Oral doxycycline was tested for its efficacy in otosyphilis.
Method:
The authors reviewed 19 patients diagnosed as having otosyphilis with hearing loss at the outpatient unit between 2004 and 2008 by oral doxycycline 400 mg/day for 21 days.
Results:
Of those enrolled patients, 12 patients were male and the mean age is 69.4 years. The hearing was improved in nine patients (47.3%) and the audiogram of seven patients (36.8%) showed improvement. There was no serious side effect of doxycycline.
Conclusion:
The data suggest that doxycycline may be an effective alternate regimen for otosyphilis.
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