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Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
06:09

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Published on: June 7, 2019

Role of the apoptotic and mitotic regulator survivin in melanoma

Jodi A McKenzie1, Douglas Grossman

  • 1Huntsman Cancer Institute, 2000 Circle of Hope Drive, Suite 5262, Salt Lake City, UT 84112, USA.

Anticancer Research
|January 31, 2012
PubMed

Insights

Survivin, a protein linked to cancer, plays a key role in melanoma development and metastasis. Understanding survivin

Area of Science:

  • Oncology
  • Molecular Biology
  • Dermatology

Background:

  • Melanoma, the deadliest skin cancer, arises from oncogenic transformation of melanocytes.
  • Metastasis is the primary cause of melanoma-related mortality, underscoring the need to understand its progression.
  • Survivin, identified in the late 1990s, is implicated in various cancers.

Purpose of the Study:

  • To review the role of survivin in melanoma biology, development, and progression.
  • To discuss survivin's established functions and newly recognized properties.
  • To explore therapeutic strategies targeting survivin in melanoma.

Main Methods:

  • Literature review of scientific publications on survivin and melanoma.
  • Analysis of survivin's known mitotic and cytoprotective roles.
  • Examination of survivin's potential contribution to melanoma metastasis and cellular motility.

Main Results:

  • Survivin exhibits established roles in mitosis and cell protection.
  • Survivin enhances cellular motility, a property potentially driving melanoma metastasis.
  • A significant body of research demonstrates survivin's involvement in various malignancies.

Conclusions:

  • Survivin is a critical factor in melanoma development, progression, and metastasis.
  • Targeting survivin presents a promising therapeutic strategy for melanoma treatment.
  • Further research into survivin's role in cellular motility is warranted.

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