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Emerging treatments for essential thrombocythemia

Steven Okoli1, Claire Harrison

  • 1Department of Haematology, Guy's and St Thomas' NHS Foundation Trust, Great Maze Pond, London, UK.

Journal of Blood Medicine
|January 31, 2012
PubMed

In 1934, Epstein and Goedel used the term hemorrhagic thrombocythemia to describe a disorder characterized by permanent elevation of a platelet count to more than three times normal, hyperplasia of megakaryocytes, and the tendency for venous thrombosis and spontaneous hemorrhage. Over the last 75 years, and particularly in the past 6 years, major progress has been made in our understanding of essential thrombocythemia (ET) and its pathogenesis with the identification of the highly prevalent JAK-2 V617F and other mutations. Current management of this condition is based upon historical data and with treatments that have not changed significantly for nearly two decades. This study discusses this and recent progress, highlighting exciting new data with old and new drugs, as well as which patients in particular should be evaluated for these new therapies.

Keywords:
JAK inhibitoressential thrombocythemiainterferon

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