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Drug Dosing: Geriatric Patients

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...

Pharmacodynamics in Geriatric Patients: Effects of Age

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...

Vaccinations

Vaccinations

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Updated: May 25, 2026

Oral Health Assessment by Lay Personnel for Older Adults

Oral Health Assessment by Lay Personnel for Older Adults

Published on: February 2, 2020

[Vaccine coverage in the elderly].

Franck Raschilas¹

¹Association pour l'assistance et la réhabilitation à domicile (Apard), Montpellier. f.raschilas@apard.com

Soins. Gerontologie

|February 1, 2012

Summary

This summary is machine-generated.

Elderly individuals are highly susceptible to infectious diseases. Achieving full vaccination coverage necessitates updated universal vaccines and specific immunizations tailored for seniors to prevent illness and mortality.

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Last Updated: May 25, 2026

Oral Health Assessment by Lay Personnel for Older Adults

Oral Health Assessment by Lay Personnel for Older Adults

Published on: February 2, 2020

Area of Science:

Gerontology
Infectious Diseases
Immunology

Context:

Elderly populations face heightened risks from infectious diseases.
Infectious diseases are a leading cause of mortality in older adults.
Vaccination is a critical public health intervention for this demographic.

Purpose:

To emphasize the importance of vaccination in the elderly population.
To highlight the need for both universal and age-specific vaccines.
To advocate for comprehensive immunization strategies for seniors.

Summary:

Infectious diseases pose a significant threat to the elderly, contributing to mortality.
Vaccination is a key strategy for preventing infections in older adults.
Optimal protection requires up-to-date universal vaccines and specialized elderly vaccines.

Impact:

Improved health outcomes for the elderly through disease prevention.
Reduced healthcare burden associated with treating infectious diseases in seniors.
Enhanced public health strategies for geriatric populations.