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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin create...
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...

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Related Experiment Videos

[Cutaneous infections in the elderly].

Hervé Maillard1

  • 1Service de dermatologie, centre hospitalier général (CHG), Le Mans. herve.maillard@free.fr

Soins. Gerontologie
|February 1, 2012
PubMed
Summary

As people age, their immune systems change, raising the risk of various infections. Elderly individuals, especially those in care settings, are particularly prone to skin infections.

Area of Science:

  • Immunology
  • Gerontology
  • Infectious Diseases

Context:

  • Immune system senescence increases susceptibility to infections in older adults.
  • Cutaneous infections are a common health concern in the elderly population.
  • Increased risk observed in both home and institutionalized elderly individuals.

Purpose:

  • To highlight the heightened vulnerability of the aging immune system.
  • To emphasize the prevalence of skin infections in the elderly.
  • To underscore the need for targeted prevention and treatment strategies.

Summary:

  • Aging is associated with significant alterations in immune function.
  • These immunological changes predispose individuals to a broad spectrum of infections, including bacterial, fungal, viral, and parasitic.

Related Experiment Videos

  • Cutaneous manifestations of infection are particularly frequent in aged populations.

    • Impact:

    • Understanding age-related immune decline is crucial for geriatric care.
    • Recognizing the increased incidence of skin infections can lead to earlier diagnosis and intervention.
    • This knowledge supports the development of tailored healthcare approaches for the elderly to combat infectious diseases.