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Updated: May 25, 2026
10:39
3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
Chronic migraine: current concepts and ongoing treatments
A Negro1, M Rocchietti-March, M Fiorillo
1Department of Medical and Molecular Sciences, Internal Medicine and Regional Referral Headache Centre, School of Health Sciences, Sapienza University of Rome, Sant'Andrea Hospital, Rome, Italy.
European Review for Medical and Pharmacological Sciences
|February 1, 2012
Summary
Chronic migraine (CM) can evolve from episodic migraine and is often linked to acute medication overuse, leading to Medication Overuse Headache (MOH). OnabotulinumtoxinA is a proven prophylactic treatment for CM.
Area of Science:
- Neurology
- Clinical Practice
Background:
- Migraine is a common neurological disorder that can become chronic, often leading to acute drug overuse and Medication Overuse Headache (MOH).
- Chronic migraine (CM) is defined by headache frequency of 15 days/month, resembling migraine attacks.
- Medication Overuse Headache (MOH) involves headaches on ≥15 days/month due to regular overuse of acute headache medications for over 3 months.
Purpose of the Study:
- To discuss the evolution of migraine into chronic forms and the associated risk factors.
- To highlight the importance of drug withdrawal in managing Medication Overuse Headache (MOH).
- To review treatment options for chronic migraine (CM), including the role of onabotulinumtoxinA.
Main Methods:
- Review of the pathophysiology and clinical presentation of chronic migraine and MOH.
- Discussion of various drug withdrawal strategies for MOH.
- Evaluation of prophylactic treatments for CM, focusing on onabotulinumtoxinA.
Main Results:
- Chronicization of migraine is associated with increased headache frequency and acute drug overuse.
- Drug withdrawal is the primary treatment for MOH, with various methods available.
- OnabotulinumtoxinA has demonstrated efficacy, safety, and tolerability as a prophylactic treatment for CM.
Conclusions:
- Effective management of CM and MOH requires addressing risk factors and implementing appropriate withdrawal strategies.
- OnabotulinumtoxinA is an approved and effective prophylactic treatment for adults with chronic migraine.
- Further research is needed to optimize the timing of prophylactic treatment initiation during drug withdrawal.
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