Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Immunodeficiency Diseases01:25

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency disorders...
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Machine learning reveals X chromosome transcriptional signatures that classify systemic lupus erythematosus in females.

BMC rheumatology·2026
Same author

Deleterious germline CARD11 gain-of-function variants alter human B-cell and CD4+ T-cell differentiation and function.

Clinical and experimental immunology·2026
Same author

CSF1R-dependent CD169-positive macrophages locally constrain melanoma growth in the skin.

The Journal of experimental medicine·2026
Same author

PI3K at the crossroads: choosing B-cell activation or tolerance.

Journal of immunology (Baltimore, Md. : 1950)·2026
Same author

NK cell dysfunction and interferon-γ production underlie autoinflammation in mevalonate kinase deficiency.

Immunity·2026
Same author

Inherited human CARD9 deficiency impairs lymphoid cell, but not fibroblast, IL-17-mediated immunity.

JCI insight·2026
Same journal

Multiomics Profiling During Autoimmune Demyelination Highlights a Complex Regulatory Role for Ataxin-1 in B Cells.

Annals of the New York Academy of Sciences·2026
Same journal

Global Trends in Light Pollution and Their Relationship With Socioeconomic Factors.

Annals of the New York Academy of Sciences·2026
Same journal

Wired for Corruption: Inter-Brain Synchrony Encodes Bribery-Related Value Information and Predicts Bribery Agreement.

Annals of the New York Academy of Sciences·2026
Same journal

LM-YOLO: A Lightweight Multi-Scale Enhanced Model for Forest Smoke Detection Using Unmanned Aerial Vehicles.

Annals of the New York Academy of Sciences·2026
Same journal

Polyrhythm Perception and Production: A Scoping Review.

Annals of the New York Academy of Sciences·2026
Same journal

DARTS-CNN-BiLSTM: Intelligent Fault Diagnosis for Computer Numerical Control Machine Tool Feed System.

Annals of the New York Academy of Sciences·2026
See all related articles

Related Experiment Video

Updated: May 25, 2026

Assessment of the Synaptic Interface of Primary Human T Cells from Peripheral Blood and Lymphoid Tissue
06:27

Assessment of the Synaptic Interface of Primary Human T Cells from Peripheral Blood and Lymphoid Tissue

Published on: July 30, 2018

T cell-B cell interactions in primary immunodeficiencies.

Stuart G Tangye1, Elissa K Deenick, Umaimainthan Palendira

  • 1Garvan Institute of Medical Research, Darlinghurst, NSW, Australia. s.tangye@garvan.org.au

Annals of the New York Academy of Sciences
|February 1, 2012
PubMed
Summary
This summary is machine-generated.

Impaired immune cell interactions disrupt T follicular helper cell formation and CD8(+) T cell responses, leading to primary immunodeficiencies and increased infection susceptibility. Understanding these defects is crucial for immune system research.

More Related Videos

Evaluation of T Follicular Helper Cells and Germinal Center Response During Influenza A Virus Infection in Mice
07:07

Evaluation of T Follicular Helper Cells and Germinal Center Response During Influenza A Virus Infection in Mice

Published on: June 27, 2020

Simultaneous Quantification of T-Cell Receptor Excision Circles (TRECs) and K-Deleting Recombination Excision Circles (KRECs) by Real-time PCR
14:14

Simultaneous Quantification of T-Cell Receptor Excision Circles (TRECs) and K-Deleting Recombination Excision Circles (KRECs) by Real-time PCR

Published on: December 6, 2014

Related Experiment Videos

Last Updated: May 25, 2026

Assessment of the Synaptic Interface of Primary Human T Cells from Peripheral Blood and Lymphoid Tissue
06:27

Assessment of the Synaptic Interface of Primary Human T Cells from Peripheral Blood and Lymphoid Tissue

Published on: July 30, 2018

Evaluation of T Follicular Helper Cells and Germinal Center Response During Influenza A Virus Infection in Mice
07:07

Evaluation of T Follicular Helper Cells and Germinal Center Response During Influenza A Virus Infection in Mice

Published on: June 27, 2020

Simultaneous Quantification of T-Cell Receptor Excision Circles (TRECs) and K-Deleting Recombination Excision Circles (KRECs) by Real-time PCR
14:14

Simultaneous Quantification of T-Cell Receptor Excision Circles (TRECs) and K-Deleting Recombination Excision Circles (KRECs) by Real-time PCR

Published on: December 6, 2014

Area of Science:

  • Immunology
  • Cell Biology
  • Genetics

Background:

  • Immune cell interactions are vital for effective immune responses and memory.
  • Defects in cell-cell interactions cause primary immunodeficiencies, leading to infections.
  • These defects impair humoral immunity and pathogen clearance.

Purpose of the Study:

  • To review the critical role of B cell and T cell interactions in immunity.
  • To discuss the formation of CD4(+) T follicular helper cells.
  • To examine how gene mutations in primary immunodeficiencies disrupt these interactions and immune functions.

Main Methods:

  • This review synthesizes existing research on immune cell interactions.
  • It analyzes the genetic basis of primary immunodeficiencies.
  • The review focuses on T follicular helper cell development and CD8(+) T cell cytotoxicity.

Main Results:

  • Effective B cell and T cell interactions are essential for CD4(+) T follicular helper cell differentiation.
  • These interactions are also critical for the cytotoxic function of virus-specific CD8(+) T cells.
  • Loss-of-function mutations in specific genes disrupt these interactions, causing primary immunodeficiencies.

Conclusions:

  • Primary immunodeficiencies result from impaired immune cell communication.
  • Understanding these defects highlights the importance of cell-cell interactions for robust immunity.
  • Targeting these interaction pathways may offer therapeutic strategies for immunodeficiencies.