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Updated: May 25, 2026
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Published on: February 6, 2019
Response to sunitinib in combination with proton beam radiation in a patient with chondrosarcoma: a case report
Jennifer Dallas1, Iman Imanirad, Rajiv Rajani
1Division of Hematology and Oncology, Department of Internal Medicine, University of Florida Shands Cancer Center, University of Florida, Gainesville, FL, USA. long.dang@medicine.ufl.edu.
Introduction:
Chondrosarcoma is well-known to be primarily resistant to conventional radiation and chemotherapy.
Case Presentation:
We present the case of a 32-year-old Caucasian man with clear cell chondrosarcoma who presented with symptomatic recurrence in his pelvis and metastases to his skull and lungs. Our patient underwent systemic therapy with sunitinib and then consolidation with proton beam radiation to his symptomatic site. He achieved complete symptomatic relief with a significantly improved performance status and had an almost complete and durable metabolic response on fluorine-18-fluorodeoxyglucose positron emission tomography.
Conclusions:
Our findings have important clinical implications and suggest novel clinical trials for this difficult to treat disease.
