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Related Experiment Video

Updated: May 25, 2026

Minimally Invasive Embryo Transfer and Embryo Vitrification at the Optimal Embryo Stage in Rabbit Model

Minimally Invasive Embryo Transfer and Embryo Vitrification at the Optimal Embryo Stage in Rabbit Model

Published on: May 16, 2019

Development and current applications of assisted fertilization.

Gianpiero D Palermo¹, Queenie V Neri, Devin Monahan

¹The Ronald O. Perelman & Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medical College, New York, New York 10021, USA. gdpalerm@med.cornell.edu

Fertility and Sterility

|February 1, 2012

Summary

Intracytoplasmic sperm injection (ICSI) revolutionized assisted reproduction, enabling fertilization even with severe male factor infertility. This technique allows the use of various sperm types, overcoming previous fertilization barriers.

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Published on: October 18, 2024

Area of Science:

Reproductive Biology
Assisted Reproductive Technology

Background:

Fertilization is a critical step in in vitro insemination.
Assisted fertilization methods were developed to overcome infertility challenges.

Observation:

Intracytoplasmic sperm injection (ICSI) emerged as a key technique.
ICSI enables fertilization using ejaculated, epididymal, and testicular spermatozoa.

Findings:

This work details the development of ICSI.
It explores current methods for selecting male gametes.
Concerns regarding offspring from severe male factor couples are discussed.

Implications:

ICSI significantly advanced assisted reproductive techniques.
Understanding gamete selection is crucial for successful outcomes.
Further research is needed on the long-term effects for offspring.