Related Experiment Video
Updated: May 25, 2026

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
Published on: August 7, 2017
Breastfeeding protects against current asthma up to 6 years of age
Karen M Silvers1, Chris M Frampton, Kristin Wickens
1Department of Paediatrics, School of Medicine and Health Sciences, University of Otago Christchurch, Christchurch, New Zealand. karen.silvers@xtra.co.nz
Insights
Exclusive breastfeeding significantly reduces current asthma in children up to age 6. Each month of exclusive breastfeeding lowered asthma risk, with greater protection observed in atopic children.
Area of Science:
- Pediatric Allergy and Immunology
- Public Health Nutrition
- Epidemiology
Background:
- Asthma is a prevalent chronic respiratory condition in childhood.
- The role of infant feeding practices, particularly breastfeeding, in asthma development requires further elucidation.
- Understanding protective factors is crucial for public health interventions.
Purpose of the Study:
- To examine the association between breastfeeding duration and the incidence of current asthma and wheezing in children aged 2 to 6 years.
- To differentiate the effects of exclusive breastfeeding versus any breastfeeding on childhood asthma.
- To investigate potential modifying effects of atopy on the breastfeeding-asthma relationship.
Main Methods:
- Prospective birth cohort study of 1105 infants in New Zealand.
- Detailed infant feeding data collected via questionnaires at multiple time points (birth, 3, 6, 15 months).
- Wheezing and current asthma assessed annually from ages 2 to 6 years; logistic regression used for analysis.
Main Results:
- Each additional month of exclusive breastfeeding was linked to a significant reduction in current asthma from ages 2 to 6 (P<.03).
- Each month of any breastfeeding reduced current asthma at ages 2, 3, and 4 (P<.005).
- In atopic children, exclusive breastfeeding for ≥3 months showed substantial reductions in current asthma at ages 4 (62%), 5 (55%), and 6 (59%).
Conclusions:
- Breastfeeding, especially exclusive breastfeeding, offers significant protection against current asthma up to age 6.
- The protective effect of exclusive breastfeeding on asthma risk is evident in all children and more pronounced in atopic children after age 3.
- Findings support breastfeeding promotion for asthma prevention in early childhood.
Objective:
To investigate the effects of breastfeeding on wheezing and current asthma in children 2 to 6 years of age.
Study Design:
Infants (n=1105) were enrolled in a prospective birth cohort in New Zealand. Detailed information about infant feeding was collected using questionnaires administered at birth and at 3, 6, and 15 months. From this, durations of exclusive and any breastfeeding were calculated. Information about wheezing and current asthma was collected at 2, 3, 4, 5, and 6 years. Logistic regression was used to model associations between breastfeeding and outcomes with and without adjustment for confounders.
Results:
After adjustment for confounders, each month of exclusive breastfeeding was associated with significant reductions in current asthma from 2 to 6 years (all, P<.03). Current asthma at 2, 3, and 4 years was also reduced by each month of any breastfeeding (all, P<.005). In atopic children, exclusive breastfeeding for ≥ 3 months reduced current asthma at ages 4, 5, and 6 by 62%, 55%, and 59%, respectively.
Conclusion:
Breastfeeding, particularly exclusive breastfeeding, protects against current asthma up to 6 years. Although exclusive breastfeeding reduced risk of current asthma in all children to age 6, the degree of protection beyond 3 years was more pronounced in atopic children.
Related Concept Videos
Asthma-I: Introduction
Asthma I: Introduction
Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla. Benzonatate operates peripherally within the respiratory tract by anesthetizing...
Asthma-IV: Nursing Management
First, in...
Asthma-III: Symptoms and Complications
Classification of Asthma
Development of Immunocompetence
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
