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Updated: May 25, 2026
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Laser Microirradiation to Study In Vivo Cellular Responses to Simple and Complex DNA Damage
Published on: January 31, 2018
ATP-dependent chromatin remodeling in the DNA-damage response
Hannes Lans1, Jurgen A Marteijn, Wim Vermeulen
1Department of Genetics, Medical Genetics Center, Erasmus MC, PO Box 2040, 3000 CA Rotterdam, The Netherlands. w.vermeulen@erasmusmc.nl.
Epigenetics & Chromatin
|February 1, 2012
Summary
ATP-dependent chromatin remodelers are crucial for DNA repair pathways. These complexes facilitate DNA repair by modifying chromatin structure, ensuring genome integrity and preventing diseases like cancer.
Area of Science:
- Molecular Biology
- Genetics
- Cell Biology
Background:
- DNA integrity is vital and constantly threatened by genotoxic agents.
- DNA damage can disrupt essential cellular processes and lead to diseases like cancer.
- Chromatin structure plays a key role in DNA repair and is regulated by the DNA-damage response.
Purpose of the Study:
- To review the current understanding of ATP-dependent chromatin remodeling in DNA repair.
- To highlight the multifaceted roles of these complexes in various DNA repair pathways.
Main Methods:
- Literature review of ATP-dependent chromatin remodeling in DNA repair.
- Focus on nucleotide excision repair, homologous recombination, and non-homologous end-joining pathways.
Main Results:
- ATP-dependent chromatin remodelers are involved in multiple DNA repair pathways.
- These complexes exhibit pleiotropic functions at different stages of DNA damage response.
- Several remodelers are implicated in distinct repair pathways, indicating versatile roles.
Conclusions:
- ATP-dependent chromatin remodeling is essential for effective DNA damage response.
- The diverse functions of these complexes underscore their importance in maintaining genome stability.
- Further research is needed to fully characterize their roles in DNA repair.
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